重排的tpr-met癌基因断点的特征分析
Characterization of the rearranged tpr-met oncogene breakpoint.
作者信息
Dean M, Park M, Vande Woude G F
出版信息
Mol Cell Biol. 1987 Feb;7(2):921-4. doi: 10.1128/mcb.7.2.921-924.1987.
Abstract
We determined the nucleotide sequence of the rearranged trp-met genomic locus and the corresponding portions of the unrearranged tpr and met genomic fragments. The breakpoints occur at one end of a stretch of 21 A residues that follow an Alu repetitive sequence in the tpr locus and within a group of 3 A residues in the met proto-oncogene locus. We conclude that the fusion between the tpr locus on chromosome 1 and the met locus on chromosome 7 resulted from a recombination event.
摘要
我们测定了重排的trp-met基因组位点以及未重排的tpr和met基因组片段相应部分的核苷酸序列。断点位于tpr基因座中一段21个A残基的一端，该段A残基紧跟Alu重复序列，且位于met原癌基因座中的一组3个A残基内。我们得出结论，1号染色体上的tpr基因座与7号染色体上的met基因座之间的融合是由重组事件导致的。
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