来自L.的两种新型生物碱及其抗炎生物活性。
Two novel alkaloids from L. and their anti-inflammatory bioactivities.
作者信息
Wang Chengyu, Guo Shengnan, Zhao Yingdai, Wang Jinhuan, Yang Ying, Ying Xixiang
机构信息
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, P.R. China.
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, P.R. China.
出版信息
Nat Prod Res. 2025 May;39(9):2558-2565. doi: 10.1080/14786419.2024.2303597. Epub 2024 Jan 13.
Two novel alkaloids were identified as (E)-N-(4-3,4-dihydroxy-6-(hydroxymethyl)-5-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxyphenyl)-3-(4-hydroxyphenyl)acrylamide , named Oleracrylimide D, (E)-N-(4-3,4-dihydroxy-6-(hydroxymethyl)-5-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide , named Oleracrylimide E, isolated from L. The structures were identified by spectroscopic methods, including 1D NMR, 2D NMR, and UHPLC-ESI-QTOF/MS methods, also, the anti-inflammatory bioactivities of the compounds were studied by ELISA method.
两种新型生物碱被鉴定为（E）-N-（4-3,4-二羟基-6-（羟甲基）-5-3,4,5-三羟基-6-（羟甲基）四氢-2H-吡喃-2-基）氧基）四氢-2H-吡喃-2-基）氧基）-2,5-二羟基苯基）-3-（4-羟基苯基）丙烯酰胺，命名为Oleracrylimide D，（E）-N-（4-3,4-二羟基-6-（羟甲基）-5-3,4,5-三羟基-6-（羟甲基）四氢-2H-吡喃-2-基）氧基）四氢-2H-吡喃-2-基）氧基）-2,5-二羟基苯基）-3-（4-羟基-3-甲氧基苯基）丙烯酰胺，命名为Oleracrylimide E，从L.中分离得到。通过包括一维核磁共振、二维核磁共振和超高效液相色谱-电喷雾电离-四极杆飞行时间质谱等光谱方法鉴定了其结构，此外，还通过酶联免疫吸附测定法研究了这些化合物的抗炎生物活性。
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