两种来自 L. 的新型酰胺生物碱及其抗炎活性。
Two novel amide alkaloids from L. and their anti-inflammatory activities.
机构信息
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
出版信息
Nat Prod Res. 2022 Nov;36(21):5567-5574. doi: 10.1080/14786419.2021.2021519. Epub 2021 Dec 29.
In this article, two novel amide alkaloids were identified as ()-3-(4-hydroxy-3-methoxyphenyl)-1-(5-hydroxy-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2-pyran-2-yl)oxy)-1-indol-1-yl)prop-2-en-1-one () and ()-1-(5-hydroxy-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2-pyran-2-yl)oxy)-1-indol-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one (), the two compounds were named oleraindole E and oleraindole F, respectively. The structures were elucidated using 1D and 2D NMR and HR-ESI-TOF-MS spectra. Additionally, the anti-inflammatory activities were evaluated on RAW264.7 cells induced by LPS, compounds and exhibited anti-inflammatory activities at 20 μM.
在本文中，鉴定出两种新型酰胺生物碱，分别为()-3-(4-羟基-3-甲氧基苯基)-1-(5-羟基-6-((3,4,5-三羟基-6-(羟甲基)四氢-2-吡喃-2-基)氧基)-1-吲哚基)-1-丙烯-2-酮()和()-1-(5-羟基-6-((3,4,5-三羟基-6-(羟甲基)四氢-2-吡喃-2-基)氧基)-1-吲哚基)-3-(4-羟基苯基)-1-丙烯-2-酮()，这两个化合物分别命名为奥来宁 E 和奥来宁 F。采用 1D 和 2D NMR 及 HR-ESI-TOF-MS 谱确定了结构。此外，还在 LPS 诱导的 RAW264.7 细胞上评估了抗炎活性，化合物和在 20μM 时表现出抗炎活性。
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