School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Nat Prod Res. 2022 Nov;36(21):5567-5574. doi: 10.1080/14786419.2021.2021519. Epub 2021 Dec 29.
In this article, two novel amide alkaloids were identified as ()-3-(4-hydroxy-3-methoxyphenyl)-1-(5-hydroxy-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2-pyran-2-yl)oxy)-1-indol-1-yl)prop-2-en-1-one () and ()-1-(5-hydroxy-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2-pyran-2-yl)oxy)-1-indol-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one (), the two compounds were named oleraindole E and oleraindole F, respectively. The structures were elucidated using 1D and 2D NMR and HR-ESI-TOF-MS spectra. Additionally, the anti-inflammatory activities were evaluated on RAW264.7 cells induced by LPS, compounds and exhibited anti-inflammatory activities at 20 μM.
在本文中，鉴定出两种新型酰胺生物碱，分别为()-3-(4-羟基-3-甲氧基苯基)-1-(5-羟基-6-((3,4,5-三羟基-6-(羟甲基)四氢-2-吡喃-2-基)氧基)-1-吲哚基)-1-丙烯-2-酮()和()-1-(5-羟基-6-((3,4,5-三羟基-6-(羟甲基)四氢-2-吡喃-2-基)氧基)-1-吲哚基)-3-(4-羟基苯基)-1-丙烯-2-酮()，这两个化合物分别命名为奥来宁 E 和奥来宁 F。采用 1D 和 2D NMR 及 HR-ESI-TOF-MS 谱确定了结构。此外，还在 LPS 诱导的 RAW264.7 细胞上评估了抗炎活性，化合物和在 20μM 时表现出抗炎活性。
