Cancer Biomark. 2024;39(3):223-230. doi: 10.3233/CBM-230157.
This article aims to investigate the clinical value of hemoglobin/red cell distribution width ratio (Hb/RDW), C-reactive protein/albumin ratio (CAR) and plateletcrit (PCT) combined with carcinoembryonic antigen (CEA) in colorectal cancer (CRC) auxiliary diagnosis.
We retrospectively analyzed in 718 subjects (212 with CRC, 209 with benign colorectal lesions (BCL), 111 with other cancers, and 186 healthy controls).
The CAR, PCT, and CEA in the CRC group were higher than those in the BCL, other cancers, and the healthy control group. However, Hb/RDW in the CRC group was lower than the other three groups. Moreover, there were significant differences in Hb/RDW and CEA among different T-N-M stages (all P< 0.05). Multivariate logistic regression showed that low level of Hb/RDW and high level of CAR, CEA, PCT were risk factors for CRC, and are correlated with CRC stage. Additionally, the area under the receiver operating characteristic curve (AUC) of Hb/RDW+CEA (AUC: 0.735), CAR+CEA (AUC: 0.748), PCT+CEA (AUC: 0.807) was larger than that of Hb/RDW (AUC: 0.503), CAR (AUC: 0.614), or PCT (AUC: 0.713) alone (all P< 0.001) in distinguishing CRC from BCL.
Hb/RDW, CAR, PCT, and CEA are independent risk factors for CRC. Hb/RDW, CAR, and PCT combined with CEA have significant value for auxiliary differential diagnosis of CRC and BCL.
本文旨在探讨血红蛋白/红细胞分布宽度比值（Hb/RDW）、C 反应蛋白/白蛋白比值（CAR）和血小板分布宽度（PCT）联合癌胚抗原（CEA）在结直肠癌（CRC）辅助诊断中的临床价值。
我们回顾性分析了 718 例患者（CRC 患者 212 例，良性结直肠病变（BCL）患者 209 例，其他癌症患者 111 例，健康对照组 186 例）。
CRC 组的 CAR、PCT 和 CEA 均高于 BCL、其他癌症和健康对照组。然而，CRC 组的 Hb/RDW 低于其他三组。此外，不同 T-N-M 分期的 Hb/RDW 和 CEA 差异有统计学意义（均 P<0.05）。多因素 logistic 回归分析显示，Hb/RDW 水平低和 CAR、CEA、PCT 水平高是 CRC 的危险因素，且与 CRC 分期相关。此外，Hb/RDW+CEA（AUC：0.735）、CAR+CEA（AUC：0.748）、PCT+CEA（AUC：0.807）的曲线下面积（AUC）大于 Hb/RDW（AUC：0.503）、CAR（AUC：0.614）或 PCT（AUC：0.713）单独用于鉴别 CRC 与 BCL（均 P<0.001）。
Hb/RDW、CAR、PCT 和 CEA 是 CRC 的独立危险因素。Hb/RDW、CAR 和 PCT 联合 CEA 对辅助鉴别诊断 CRC 和 BCL 具有重要价值。
