Boutibonnes P, Auffray Y
Mutat Res. 1987 Feb;190(2):83-7. doi: 10.1016/0165-7992(87)90036-4.
Bacillus thuringiensis is shown to have an inducible error-free repair system for alkylation damage as found in Escherichia coli and Bacillus subtilis. Growth of cells in the presence of low concentrations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induces an adaptive response which is characterized by an increase in resistance to killing and mutagenesis by challenge with higher concentrations of MNNG. In addition, we have noted with interest that adaptive low doses seem to produce lesions at a rate sufficient to induce an increase of mutation frequency, and inhibition of cell division. The possibility of an interaction between SOS and adaptive responses with these low doses of MNNG is discussed.
苏云金芽孢杆菌被证明拥有一种可诱导的无差错修复系统，用于修复烷基化损伤，这与在大肠杆菌和枯草芽孢杆菌中发现的情况相同。在低浓度的N-甲基-N'-硝基-N-亚硝基胍（MNNG）存在下培养细胞会诱导一种适应性反应，其特征是在用更高浓度的MNNG攻击时，对杀伤和诱变的抗性增加。此外，我们感兴趣地注意到，适应性低剂量似乎以足以诱导突变频率增加和抑制细胞分裂的速率产生损伤。本文讨论了SOS反应与这些低剂量MNNG的适应性反应之间相互作用的可能性。
