弗氏链霉菌中氯霉素对N-甲基-N'-硝基-N-亚硝基胍诱变的适应性反应及增强作用
Adaptive response and enhancement of N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis by chloramphenicol in Streptomyces fradiae.
作者信息
Baltz R H, Stonesifer J
出版信息
J Bacteriol. 1985 Nov;164(2):944-6. doi: 10.1128/jb.164.2.944-946.1985.
Abstract
Streptomyces fradiae expressed an adaptive response to treatment with small doses of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) that caused a reduction in mutagenesis by treatment with larger doses of MNNG. Treatment of S. fradiae with high levels of MNNG in the presence of chloramphenicol caused enhancement of mutagenesis, independent of the adaptive response.
摘要
弗氏链霉菌对小剂量N-甲基-N'-硝基-N-亚硝基胍（MNNG）处理表现出适应性反应，这种反应导致用大剂量MNNG处理时诱变作用降低。在氯霉素存在的情况下，用高水平MNNG处理弗氏链霉菌会导致诱变作用增强，且与适应性反应无关。
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