Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang, 550001, China.
Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang, 550001, China.
Mol Biol Rep. 2024 Jan 13;51(1):101. doi: 10.1007/s11033-023-09081-1.
Diabetes is a chronic disease in metabolic disorder, and the pathology is characterized by insulin resistance and insulin secretion disorder in blood. In current, many studies have revealed that polysaccharides extracted from natural sources with significant anti-diabetic effects. Natural polysaccharides can ameliorate diabetes through different action mechanisms. All these polysaccharides are expected to have an important role in the clinic.
Existing polysaccharides for the treatment of diabetes are reviewed, and the mechanism of polysaccharides in the treatment of diabetes and its structural characteristics are described in detail.
This article introduced the natural polysaccharide through different mechanisms of action in the treatment of diabetes, including oxidative stress, apoptosis, inflammatory response and regulation of intestinal bacteria. Natural polysaccharides can treat of diabetes by regulating signaling pathways is also a research hotspot. In addition, the structural characteristics of polysaccharides were explored. There are some structure-activity relationships between natural polysaccharides and the treatment of diabetes.
糖尿病是一种代谢紊乱的慢性疾病，其病理特征为血液中存在胰岛素抵抗和胰岛素分泌紊乱。目前，许多研究表明，从天然来源提取的具有显著抗糖尿病作用的多糖。天然多糖可以通过不同的作用机制改善糖尿病。所有这些多糖都有望在临床上发挥重要作用。
综述了现有的治疗糖尿病的多糖，详细描述了多糖在治疗糖尿病中的作用机制及其结构特征。
本文通过不同的作用机制介绍了天然多糖在治疗糖尿病中的应用，包括氧化应激、细胞凋亡、炎症反应和肠道细菌调节。多糖通过调节信号通路来治疗糖尿病也是一个研究热点。此外，还探讨了多糖的结构特征。天然多糖与治疗糖尿病之间存在一些结构-活性关系。
