使用四种间接方法建立癌胚抗原（CEA）、甲胎蛋白（AFP）、癌抗原125（CA125）和癌抗原199（CA199）参考区间的结果比较及年龄相关变化
Comparison of results and age-related changes in establishing reference intervals for CEA, AFP, CA125, and CA199 using four indirect methods.
作者信息
Chen Juping, Fan Lina, Yang Zheng, Yang Dagan
机构信息
Department of Laboratory Medicine, Liangzhu Branch of the First Affiliated Hospital of Zhejiang University, Zhejiang, China.
School of Public Health, Zhejiang University School of Medicine, Zhejiang, China.
出版信息
Pract Lab Med. 2023 Dec 27;38:e00353. doi: 10.1016/j.plabm.2023.e00353. eCollection 2024 Jan.
•The reference intervals calculated using RefineR, Kosmic, TMC, and non-parametric methods are similar.•TMC algorithm is more robust, demonstrates a high pass rate among the four methods and has the ability to automatically isolate outliers.•The reference intervals of CA125 and CA199 showed significant differences between age and sex.
•使用RefineR、Kosmic、TMC和非参数方法计算出的参考区间相似。
•TMC算法更稳健，在四种方法中通过率较高，并且有能力自动分离异常值。
•CA125和CA199的参考区间在年龄和性别之间存在显著差异。
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