Tay Roland Yingjie, Song Yu, Yao Dickson R, Gao Wei
Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, California, 91125, USA.
School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Mater Today (Kidlington). 2023 Dec;71:135-151. doi: 10.1016/j.mattod.2023.09.006. Epub 2023 Sep 30.
The development of wearable and implantable bioelectronics has garnered significant momentum in recent years, driven by the ever-increasing demand for personalized health monitoring, remote patient management, and real-time physiological data collection. The elevated sophistication and advancement of these devices have thus led to the use of many new and unconventional materials which cannot be fulfilled through traditional manufacturing techniques. Three-dimension (3D) printing, also known as additive manufacturing, is an emerging technology that opens new opportunities to fabricate next-generation bioelectronic devices. Some significant advantages include its capacity for material versatility and design freedom, rapid prototyping, and manufacturing efficiency with enhanced capabilities. This review provides an overview of the recent advances in 3D printing of bioelectronics, particularly direct ink writing (DIW), encompassing the methodologies, materials, and applications that have emerged in this rapidly evolving field. This review showcases the broad range of bioelectronic devices fabricated through 3D printing including wearable biophysical sensors, biochemical sensors, electrophysiological sensors, energy devices, multimodal systems, implantable devices, and soft robots. This review will also discuss the advantages, existing challenges, and outlook of applying DIW 3D printing for the development of bioelectronic devices toward healthcare applications.
近年来，由于对个性化健康监测、远程患者管理和实时生理数据收集的需求不断增加，可穿戴和植入式生物电子学的发展势头迅猛。这些设备日益复杂和先进，因此导致了许多新型和非常规材料的使用，而传统制造技术无法满足这些需求。三维（3D）打印，也称为增材制造，是一种新兴技术，为制造下一代生物电子设备带来了新机遇。其一些显著优势包括材料通用性和设计自由度高、快速成型以及制造效率高且能力增强。本综述概述了生物电子学3D打印的最新进展，特别是直接墨水书写（DIW），涵盖了在这个快速发展的领域中出现的方法、材料和应用。本综述展示了通过3D打印制造的广泛生物电子设备，包括可穿戴生物物理传感器、生化传感器、电生理传感器、能量设备、多模态系统、植入式设备和软机器人。本综述还将讨论将DIW 3D打印应用于生物电子设备以用于医疗保健应用的优势、现有挑战和前景。
