α-Glucosidase Inhibitory Activity and Cytotoxicity of CeO Nanoparticles Fabricated Using a Mixture of Different Cerium Precursors.

A mixture of three distinct cerium precursors (Ce(NO)·6HO, CeCl·7HO, and Ce(CHCOO)·HO) was used to prepare cerium oxide nanoparticles (CeO NPs) in a polyol-mediated synthesis. Different ratios of diethylene glycol (DEG) and HO were utilized in the synthesis. The properties of the synthesized CeO NPs, such as structural and morphological properties, were investigated to observe the effect of the mixed cerium precursors. Crystallite sizes of 7-8 nm were obtained for all samples, and all synthesized samples were confirmed to be in the cubic phase. The average particle sizes of the spherical CeO were between 9 and 13 nm. The successful synthesis of CeO can also be confirmed via the vibrational band of Ce-O from the FTIR. Antidiabetic properties of the synthesized CeO NPs were investigated using α-glucosidase enzyme inhibition assay, and the concentration of the synthesized CeO NPs was varied in the study. The biocompatibility properties of the synthesized CeO NPs were investigated via cytotoxicity tests, and it was found that all synthesized materials showed no cytotoxic properties at lower concentrations (62.5-125 μg/mL).