Mori de Moro G, Duffard R, Evangelista de Duffard A M
Neurotoxicology. 1986 Fall;7(3):173-80.
Previous studies have shown that 2,4-Dichlorophenoxyacetic butyl ester (2,4-D b.e.) causes hypomyelination in chicks born from eggs externally treated and alters the myelin chemical composition. In this paper the effect of 2,4-D b.e. on myelin phospholipid and fatty acid composition has been examined. The results of our investigations show significant variations in the phospholipid composition, with the phosphatidyl inositol content increased and sphingomyelin and phosphatidyl ethanolamine contents diminished. The fatty acid pattern of the individual myelin lipids is also significantly altered, with an important reduction of long chain fatty acids and an increase of saturated fatty acids. The observed changes in the chemical composition implicate alterations in the intrinsic properties of this membrane.
先前的研究表明，2,4-二氯苯氧乙酸丁酯（2,4-D丁酯）会导致经外部处理的鸡蛋孵化出的雏鸡出现髓鞘形成不足，并改变髓磷脂的化学成分。在本文中，研究了2,4-D丁酯对髓磷脂磷脂和脂肪酸组成的影响。我们的研究结果表明，磷脂组成存在显著差异，磷脂酰肌醇含量增加，鞘磷脂和磷脂酰乙醇胺含量减少。单个髓磷脂脂质的脂肪酸模式也发生了显著变化，长链脂肪酸大幅减少，饱和脂肪酸增加。观察到的化学成分变化表明该膜的内在特性发生了改变。
