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采用特殊指标对糖尿病管理和治疗效果的分析

Analysis of the management and therapeutic performance of diabetes mellitus employing special target.

作者信息

Sun Hong-Yan, Lin Xiao-Yan

机构信息

Department of Endocrine and Metabolic Diseases, Yantaishan Hospital, Yantai 264003, Shandong Province, China.

出版信息

World J Diabetes. 2023 Dec 15;14(12):1721-1737. doi: 10.4239/wjd.v14.i12.1721.

Abstract

Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantly by hyperglycemia. The most common causes contributing to the pathophysiology of diabetes are insufficient insulin secretion, resistance to insulin's tissue-acting effects, or a combination of both. Over the last 30 years, the global prevalence of diabetes increased from 4% to 6.4%. If no better treatment or cure is found, this amount might climb to 430 million in the coming years. The major factors of the disease's deterioration include age, obesity, and a sedentary lifestyle. Finding new therapies to manage diabetes safely and effectively without jeopardizing patient compliance has always been essential. Among the medications available to manage DM on this journey are glucagon-like peptide-1 agonists, thiazolidinediones, sulphonyl urease, glinides, biguanides, and insulin-targeting receptors discovered more than 10 years ago. Despite the extensive preliminary studies, a few clinical observations suggest this process is still in its early stages. The present review focuses on targets that contribute to insulin regulation and may be employed as targets in treating diabetes since they may be more efficient and secure than current and traditional treatments.

摘要

糖尿病(DM)是一种主要以高血糖为特征的慢性代谢性疾病。导致糖尿病病理生理的最常见原因是胰岛素分泌不足、对胰岛素组织作用效应的抵抗或两者兼而有之。在过去30年中,全球糖尿病患病率从4%上升到了6.4%。如果找不到更好的治疗方法或治愈方法,未来几年这一数字可能会攀升至4.3亿。疾病恶化的主要因素包括年龄、肥胖和久坐不动的生活方式。在不影响患者依从性的情况下,找到安全有效的糖尿病治疗新方法一直至关重要。在这一过程中可用于治疗糖尿病的药物包括胰高血糖素样肽-1激动剂、噻唑烷二酮类、磺酰脲类、格列奈类、双胍类以及10多年前发现的胰岛素靶向受体。尽管进行了广泛的初步研究,但一些临床观察表明这一过程仍处于早期阶段。本综述重点关注有助于胰岛素调节的靶点,这些靶点可作为治疗糖尿病的靶点,因为它们可能比目前的传统治疗方法更有效、更安全。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21ec/10784800/297eca17d820/WJD-14-1721-g001.jpg

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