Arshad Kiran, Hanan Sheikh Danial, Younis Muhammad Numair, Badar Rimsha, Imran Minahil, Numair Nefal, Imran Abubakar
Department of Allied Health Sciences, Fatima Memorial Hospital, Lahore, Punjab, Pakistan.
Department of Medical Imaging Technology, NUR International University, Lahore, Punjab, Pakistan.
Euroasian J Hepatogastroenterol. 2023 Jul-Dec;13(2):66-72. doi: 10.5005/jp-journals-10018-1409.
Hepatocellular carcinoma (HCC), ranks as the third most prevalent malignancy contributing to cancer-related death on a global scale. Hepatocellular carcinoma is known to be the fifth most frequently diagnosed malignancy of the males while among females, it is ranked as the seventh most common malignancy. The study was conducted to detect the sensitivity of primary HCC using F-flourodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) scan.
This prospective study was conducted to identify the primary HCC in a sample size of 51 patients, in whom FDG PET-CT scan was performed between May 2022 and December 2022.
Among the cohort of 51 patients, primary HCC was detected on FDG PET-CT in 43 individuals representing true-positive cases. Conversely, FDG PET-CT was unable to detect HCC in 8 cases, representing false-negative. Out of 51 patients, 74.5% of HCC cases exhibited multifocal pattern. The maximum standardized uptake value (SUV max) of the primary malignant site ranged from 1.9 to 16.1, with a mean of 3.7 ± 2.8. The FDG PET-CT revealed abnormal sites of the uptake outside liver in 23 individuals. The research confirmed the tumor recurrence in four previously treated patients. In the conducted investigation, FDG PET-CT showed 84.3% sensitivity for the diagnosis of HCC.
The study demonstrates that FDG PET-CT is a viable option for the detection of HCC. The sensitivity of FDG PET-CT in our population is comparable and in agreement with international data for diagnosis of HCC thereby favoring its reproducibility among geographical and ethnic groups. However, owing to the reduced ability of FDG PET-CT scan to identify well-differentiated/low-grade HCC, the routine use of FDG PET-CT scan may not be considered in cases requiring evaluation of primary disease only.
Arshad K, Hanan SD, Younis MN, . Detection of Primary Hepatocellular Carcinoma on F-Fluorodeoxyglucose Positron Emission Tomography-computed Tomography. Euroasian J Hepato-Gastroenterol 2023;13(2):66-72.
肝细胞癌（HCC）是全球范围内导致癌症相关死亡的第三大常见恶性肿瘤。已知肝细胞癌是男性中第五大最常被诊断出的恶性肿瘤，而在女性中，它被列为第七大常见恶性肿瘤。本研究旨在通过F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（FDG PET-CT）检测原发性肝细胞癌的敏感性。
本前瞻性研究旨在对51例患者进行原发性肝细胞癌的鉴定，这些患者在2022年5月至2022年12月期间接受了FDG PET-CT扫描。
在这51例患者中，43例通过FDG PET-CT检测到原发性肝细胞癌，为真阳性病例。相反，FDG PET-CT未能在8例中检测到肝细胞癌，为假阴性。在51例患者中，74.5%的肝细胞癌病例呈现多灶性模式。原发性恶性部位的最大标准化摄取值（SUV max）范围为1.9至16.1，平均值为3.7±2.8。FDG PET-CT显示23例患者肝脏外有异常摄取部位。该研究证实了4例先前接受治疗的患者出现肿瘤复发。在本次调查中，FDG PET-CT对肝细胞癌诊断的敏感性为84.3%。
该研究表明FDG PET-CT是检测肝细胞癌的可行选择。我们人群中FDG PET-CT的敏感性与国际上肝细胞癌诊断数据相当且一致，因此有利于其在不同地理和种族群体中的重复性。然而由于FDG PET-CT扫描识别高分化/低级别肝细胞癌的能力降低，在仅需要评估原发性疾病的情况下，可能不考虑常规使用FDG PET-CT扫描。
Arshad K, Hanan SD, Younis MN, . F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描检测原发性肝细胞癌。《欧亚肝脏胃肠病学杂志》2023；13(2):66-72。
