Yordan E L, Schlaerth J, Gaddis O, Morrow C P
Obstet Gynecol. 1987 Apr;69(4):627-30.
The Albert Mathieu Chorionepithelioma Registry's 1800 cases were screened, and 70 cases of trophoblastic disease involving the central nervous system were abstracted. In addition, eight patients with central nervous system trophoblastic disease from the Western Trophoblastic Disease Center, Department of Obstetrics and Gynecology, University of Southern California (USC) Medical Center, were reviewed. Eighteen patients received chemotherapy and whole-brain irradiation, 25 were treated with chemotherapy alone, and 35 received neither chemotherapy nor irradiation. In the no-treatment group (in which most patients died before therapy was begun), there were no survivors, and 74% of the deaths resulted from central nervous system causes. In the chemotherapy-alone group, 24% survived and 58% died of central nervous system causes. In the chemotherapy and irradiation group, 50% survived but none of the deaths were due to central nervous system involvement. This study suggests that radiation has a distinct therapeutic role in the treatment of central nervous system choriocarcinoma, and provides evidence that the irradiated brain tends to resist recurrent disease even in those patients for whom the outcome is fatal.
对阿尔贝·马蒂厄绒毛膜上皮癌登记处的1800例病例进行了筛查，提取出70例累及中枢神经系统的滋养层疾病病例。此外，还对南加州大学（USC）医学中心妇产科西部滋养层疾病中心的8例中枢神经系统滋养层疾病患者进行了回顾。18例患者接受了化疗和全脑照射，25例仅接受化疗，35例既未接受化疗也未接受照射。在未治疗组（大多数患者在开始治疗前死亡）中，没有幸存者，74%的死亡是由中枢神经系统原因导致的。在仅接受化疗组中，24%存活，58%死于中枢神经系统原因。在化疗和照射组中，50%存活，但没有一例死亡是由于中枢神经系统受累。这项研究表明，放疗在中枢神经系统绒毛膜癌的治疗中具有独特的治疗作用，并提供了证据表明，即使对于那些结局致命的患者，接受放疗的脑部也倾向于抵抗复发性疾病。
