Malczak Izabela, Gajda Anna
Department of Pharmacology and Toxicology, National Veterinary Research Institute, Partyzantów 57, 24-100, Poland.
J Pharm Anal. 2023 Dec;13(12):1452-1470. doi: 10.1016/j.jpha.2023.09.014. Epub 2023 Sep 23.
Antibiotics are among the most often used medications in human healthcare and agriculture. Overusing these substances can lead to complications such as increasing antibiotic resistance in bacteria or a toxic effect when administering large amounts. To solve these problems, new solutions in antibacterial therapy are needed. The use of natural products in medicine has been known for centuries. Some of them have antibacterial activity, hence the idea to combine their activity with commercial antibiotics to reduce the latter's use. This review presents collected information on natural compounds (terpenes, alkaloids, flavonoids, tannins, sulfoxides, and mycotoxins), of which various drug interactions have been observed. Many of the indicated compounds show synergistic or additive interactions with antibiotics, which suggests their potential for use in antibacterial therapy, reducing the toxicity of the antibiotics used and the risk of further development of bacterial resistance. Unfortunately, there are also compounds which interact antagonistically, potentially hindering the therapy of bacterial infection. Depending on its mechanism of action, each compound can behave differently in combination with different antibiotics and when acting against various bacterial strains.
抗生素是人类医疗保健和农业中最常用的药物之一。过度使用这些物质会导致并发症，如细菌对抗生素的耐药性增加，或大量使用时产生毒性作用。为了解决这些问题，需要抗菌治疗的新解决方案。天然产物在医学中的应用已有数百年历史。其中一些具有抗菌活性，因此有将其活性与商业抗生素结合以减少后者使用的想法。本综述介绍了有关天然化合物（萜类、生物碱、黄酮类、单宁、亚砜和霉菌毒素）的收集信息，已观察到它们之间存在各种药物相互作用。许多所示化合物与抗生素显示出协同或相加相互作用，这表明它们在抗菌治疗中的应用潜力，可降低所用抗生素的毒性以及细菌耐药性进一步发展的风险。不幸的是，也有一些化合物表现出拮抗作用，可能会阻碍细菌感染的治疗。根据其作用机制，每种化合物与不同抗生素联合使用以及对抗各种细菌菌株时的表现可能会有所不同。
