Cui Wenjing, Wang Yadong, Zhang Li, Liu Fang, Duan Guangcai, Chen Shuaiyin, Long Jinzhao, Jin Yuefei, Yang Haiyan
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, Henan 450016, P.R. China.
Med Int (Lond). 2024 Aug 30;4(6):67. doi: 10.3892/mi.2024.191. eCollection 2024 Nov-Dec.
As a notorious bacterial pathogen, () can readily induce infections in the community and hospital, causing significant morbidity and mortality. With the extensive rise of multiple resistance, conventional antibiotic therapy has rapidly become ineffective for related infections. Resveratrol is a naturally occurring polyphenolic substance that has been demonstrated to have effective antimicrobial activity against Resveratrol at sub-inhibitory doses can suppress the expression of virulence factors, contributing to attenuated biofilm formation, interference with quorum sensing and the inhibition of the production of toxins. As a promising efflux pump inhibitor, resveratrol enhances antibiotic susceptibility to a certain extent. In conjunction with conventional antibiotics, resveratrol displays unique synergistic effects with norfloxacin and aminoglycoside on , yet antagonizes the lethal effects of daptomycin, oxacillin, moxifloxacin and levofloxacin. Nevertheless, given the low oral bioavailability of resveratrol, advanced formulations need to be developed to delay the rapid metabolism conversion to low or inactive conjugates. The present review discusses the antibacterial properties of resveratrol against , in an aim to provide in-depth insight for researchers to address the challenges of antimicrobial resistance.
作为一种臭名昭著的细菌病原体，（）很容易在社区和医院引发感染，导致显著的发病率和死亡率。随着多重耐药性的广泛增加，传统抗生素疗法对相关感染迅速变得无效。白藜芦醇是一种天然存在的多酚类物质，已被证明对（）具有有效的抗菌活性。亚抑制剂量的白藜芦醇可以抑制毒力因子的表达，有助于减少生物膜形成、干扰群体感应并抑制毒素产生。作为一种有前景的外排泵抑制剂，白藜芦醇在一定程度上增强了抗生素敏感性。与传统抗生素联合使用时，白藜芦醇与诺氟沙星和氨基糖苷类药物对（）显示出独特的协同作用，但拮抗达托霉素、苯唑西林、莫西沙星和左氧氟沙星的致死作用。然而，鉴于白藜芦醇口服生物利用度低，需要开发先进的制剂来延缓其快速代谢转化为低活性或无活性的结合物。本综述讨论了白藜芦醇对（）的抗菌特性，旨在为研究人员应对抗菌耐药性挑战提供深入见解。
