Department of Orthopedics, Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu Province, China.
Afr Health Sci. 2023 Jun;23(2):360-366. doi: 10.4314/ahs.v23i2.40.
Knee osteoarthritis (KOA) is a common chronic progressive disease. We aimed to evaluate the effects of ozone combined with articular injection of sodium hyaluronate on KOA patients and their inflammatory factors and hemorheological indices.
A total of 292 KOA patients treated from October 2020 to October 2021 were randomly divided into observation and control groups (n=146). Observation group was treated with ozone combined with articular injection of sodium hyaluronate, while control group was routinely given glucosamine hydrochloride tablets and articular injection of sodium hyaluronate. The treatment was performed once a week for 5 consecutive weeks. Their general data, treatment outcomes, visual analogue scale (VAS) score, Hospital for Special Surgery (HSS) knee score, inflammatory factor levels and hemorheological indices were compared.
After treatment, observation group had significantly lower VAS score and higher HSS score than those of control group (P<0.05). The total response rate of observation group was higher than that of control group (P<0.05). The levels of inflammatory factors in the joint fluid were significantly lower in observation group than those in control group (P<0.05). The hemorheological indices were improved in both groups, especially in observation group (P<0.05).
Ozone combined with articular injection of sodium hyaluronate has obvious therapeutic effects on KOA.
膝骨关节炎（KOA）是一种常见的慢性进行性疾病。本研究旨在评估臭氧联合关节内注射透明质酸钠对 KOA 患者及其炎症因子和血液流变学指标的影响。
选择 2020 年 10 月至 2021 年 10 月期间接受治疗的 292 例 KOA 患者，采用随机数字表法分为观察组和对照组，每组 146 例。观察组采用臭氧联合关节内注射透明质酸钠治疗，对照组给予常规盐酸氨基葡萄糖片联合关节内注射透明质酸钠治疗。每周治疗 1 次，连续治疗 5 周。比较两组患者的一般资料、治疗效果、视觉模拟评分（VAS）、美国特种外科医院（HSS）膝关节评分、炎症因子水平和血液流变学指标。
治疗后，观察组 VAS 评分低于对照组，HSS 评分高于对照组（P<0.05）。观察组总有效率高于对照组（P<0.05）。观察组关节液中炎症因子水平低于对照组（P<0.05）。两组血液流变学指标均有所改善，观察组改善更明显（P<0.05）。
臭氧联合关节内注射透明质酸钠治疗 KOA 具有显著疗效。
