Department of Chemistry, Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Department of Pharmaceutical Microbiology, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
ACS Appl Mater Interfaces. 2024 Jan 24;16(3):3116-3125. doi: 10.1021/acsami.3c15083. Epub 2024 Jan 15.
High concentrations of reactive oxygen and nitrogen species (RONS) are key characteristics of inflammatory sites. Scavenging RONS at the site of inflammation is an effective therapeutic strategy. This study introduces ultrasmall CuO@His nanoparticles with RONS-scavenging ability for the treatment of inflammatory bowel disease (IBD) in mice. The strong coordination between the nitrogen atom in histidine (His) and copper enhances the dispersion and stability of CuO@His. Due to their small size and large surface area, CuO@His exhibits outstanding RONS-clearing ability. Importantly, CuO@His can target mitochondrial sites and repair damaged mitochondria. With excellent dispersion and scavenging RONS ability, CuO@His demonstrates good efficacy in treating mouse IBD. This work provides a new paradigm for developing nanozymes with an ultrasmall size and multiple scavenging RONS abilities.
高浓度的活性氧和氮物种 (RONS) 是炎症部位的关键特征。在炎症部位清除 RONS 是一种有效的治疗策略。本研究介绍了具有 RONS 清除能力的超小 CuO@His 纳米粒子，用于治疗小鼠的炎症性肠病 (IBD)。组氨酸 (His) 中的氮原子与铜之间的强配位作用增强了 CuO@His 的分散性和稳定性。由于其尺寸小、比表面积大，CuO@His 表现出出色的 RONS 清除能力。重要的是，CuO@His 可以靶向线粒体部位并修复受损的线粒体。由于具有出色的分散性和清除 RONS 的能力，CuO@His 在治疗小鼠 IBD 方面表现出良好的疗效。这项工作为开发具有超小尺寸和多种清除 RONS 能力的纳米酶提供了新的范例。
