Molinaro Stefano, Russo Riccardo, Mistretta Francesco, Risi Gaetano, Gava Umberto Amedeo, Bergui Mauro
Interventional Neuroradiology Unit, AOU Città della Salute e della Scienza, Torino, Italy.
Department of Neuroradiology, Università degli Studi di Torino, Torino, Italy.
Neurointervention. 2024 Mar;19(1):6-13. doi: 10.5469/neuroint.2023.00500. Epub 2024 Jan 16.
Mechanical thrombectomy (MT) is the standard of care for acute ischemic stroke (AIS) due to large vessel occlusion (LVO). The choice of a transradial approach (TRA) for anterior circulation LVOs is still debatable; the use of a specific tricoaxial system could help mitigate numerous issues related to transradial MT.
From November 2022 to November 2023, 22 patients underwent TRA-MT for anterior circulation LVOs, both as first-line and rescue from transfemoral approach (TFA) failure, with the same triaxial setup consisting of a 7F introducer sheath, 7F guide catheter, and aspiration catheters ranging from 5.5F to 5F in relation to the occlusion site. Choice of thrombectomy technique was at operator discretion. Patients' demographic data, clinical presentation, treatment details, complications, rate of crossover to TFA, successful revascularization (modified thrombolysis in cerebral infarction [mTICI] score ≥2b), and good clinical outcome at 3 months (modified Rankin scale [mRS] 0-2) were reported.
Of 20 patients selected, 10 (50%) had occlusion of M1 segment of middle cerebral artery (MCA), 6 (30%) of internal carotid artery (ICA) terminus, and 4 (20%) with M2 MCA occlusions; 12/20 (60%) were right-sided occlusions and 8/20 (40%) were left-sided. The mean National Institutes of Health Stroke Scale score was 9.25 at admission. Successful revascularization to mTICI 2b-3 was achieved in 18/20 patients (90%). Intracranial complications were reported in 2 (10%) patients. Rate of radial artery occlusion at 24 hours was 10,6%; no access-site haemorrhagic complications were reported. Symptomatic intracranial hemorrhage occurred in 2 (10%) patients. mRS score 0-2 at 3 months was 50%.
The high technical effectiveness and good safety profile of this specific tricoaxial setup for TRA-MT in AIS, even for large proximal LVOs, could constitute a viable alternative to TFA-MT in selected cases.
机械取栓术(MT)是治疗因大血管闭塞(LVO)导致的急性缺血性卒中(AIS)的标准治疗方法。对于前循环LVO采用经桡动脉入路(TRA)仍存在争议;使用特定的同轴系统可能有助于缓解与经桡动脉MT相关的诸多问题。
2022年11月至2023年11月,22例患者因前循环LVO接受了TRA-MT,包括作为一线治疗以及在经股动脉入路(TFA)失败后进行的补救治疗,均采用相同的同轴设置,即7F导入鞘、7F引导导管以及根据闭塞部位选择5.5F至5F的抽吸导管。取栓技术由术者自行决定。报告了患者的人口统计学数据、临床表现、治疗细节、并发症、转为TFA的比例、成功再灌注(改良脑梗死溶栓[mTICI]评分≥2b)以及3个月时良好的临床结局(改良Rankin量表[mRS]0-2)。
入选的20例患者中(译者注:原文此处写的是22例,后面结果部分又说20例,疑有误,按20例翻译),10例(50%)大脑中动脉(MCA)M1段闭塞,6例(30%)颈内动脉(ICA)末端闭塞,4例(20%)MCA M2段闭塞;12/20(60%)为右侧闭塞,8/20(40%)为左侧闭塞。入院时美国国立卫生研究院卒中量表平均评分为9.25。18/20例患者(90%)成功再灌注至mTICI 2b-3级。2例(10%)患者报告有颅内并发症。24小时桡动脉闭塞率为10.6%;未报告穿刺部位出血并发症。2例(10%)患者发生有症状性颅内出血。3个月时mRS评分0-2级的比例为50%。
这种用于AIS中TRA-MT的特定同轴设置具有较高的技术有效性和良好的安全性,即使对于近端大血管LVO也是如此,在某些情况下可能是TFA-MT的可行替代方案。