果蝇和脊椎动物翻译起始位点侧翼共有序列的比较。
Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.
作者信息
Cavener D R
出版信息
Nucleic Acids Res. 1987 Feb 25;15(4):1353-61. doi: 10.1093/nar/15.4.1353.
Abstract
The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CAAAACAUG.
摘要
科扎克此前提出的真核生物翻译起始位点的共有序列基本上源自脊椎动物的mRNA序列。果蝇的核基因表现出明显不同的翻译起始共有序列。这些差异可能并不代表翻译起始机制上的差异，因为这两个类群在关键的-3位置表现出相同的偏好和限制。使用更保守的共有序列分配标准得出了以下共有序列：脊椎动物——CANCAUG，果蝇——CAAAACAUG。
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