• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

冷激活棕色脂肪组织与肥胖青年人群中心血管代谢功能障碍减少相关。

Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity.

机构信息

Division of Adolescent Medicine, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.

Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.

出版信息

Obesity (Silver Spring). 2020 May;28(5):916-923. doi: 10.1002/oby.22767. Epub 2020 Mar 13.

DOI:10.1002/oby.22767
PMID:32170839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7180112/
Abstract

OBJECTIVE

This study aimed to test the hypothesis that young adults with obesity and cold-activated brown adipose tissue (BAT) are less likely to have metabolic dysfunction (dyslipidemia, insulin resistance, and hypertension) than those without cold-activated BAT. Previous studies have noted a potentially protective effect of BAT and higher adiponectin/leptin ratios, but they have acknowledged that the clinical implications of these findings remain uncertain.

METHODS

Twenty-one females and twenty-three males with obesity (BMI ≥ 30 kg/m ) underwent a 2-hour cooling protocol before F-fluorodeoxyglucose ( F-FDG)-positron emission tomography/x-ray computed tomography scan to determine the prevalence, volume, and  F-FDG uptake of cold-activated BAT.

RESULTS

Cold-activated BAT was identified in 43% of participants (11 female, 8 male); females had greater  F-FDG uptake. Those with cold-activated BAT had a lesser degree of metabolic dysfunction. Cold-activated BAT volume correlated with triglycerides (inversely) and adiponectin (concordantly). Body-mass-adjusted cold-activated BAT activity correlated with high-density lipoprotein cholesterol (concordantly). Males with cold-activated BAT had lower leptin and higher adiponectin/leptin ratio.

CONCLUSIONS

A high prevalence of cold-activated BAT was found in the study participants. BAT could be important in decreasing metabolic dysfunction among young adults with obesity, making it a potential target for treating metabolically unhealthy obesity.

摘要

目的

本研究旨在检验以下假设，即患有肥胖症且冷激活棕色脂肪组织（BAT）的年轻人比没有冷激活 BAT 的同龄人更不易出现代谢功能障碍（血脂异常、胰岛素抵抗和高血压）。先前的研究注意到 BAT 和更高的脂联素/瘦素比值可能具有保护作用，但它们承认这些发现的临床意义仍不确定。

方法

21 名女性和 23 名男性肥胖者（BMI≥30kg/m²）接受了 2 小时的冷却方案，然后进行 F-氟脱氧葡萄糖（ F-FDG）-正电子发射断层扫描/X 射线计算机断层扫描，以确定冷激活 BAT 的患病率、体积和 F-FDG 摄取。

结果

43%的参与者（11 名女性，8 名男性）存在冷激活 BAT；女性的 F-FDG 摄取量更大。存在冷激活 BAT 的人代谢功能障碍程度较轻。冷激活 BAT 体积与甘油三酯（呈负相关）和脂联素（呈正相关）相关。校正体重后的冷激活 BAT 活性与高密度脂蛋白胆固醇（呈正相关）相关。存在冷激活 BAT 的男性瘦素较低，脂联素/瘦素比值较高。

结论

研究参与者中冷激活 BAT 的患病率较高。BAT 可能在降低肥胖年轻成年人的代谢功能障碍方面发挥重要作用，使其成为治疗代谢不健康性肥胖的潜在靶点。

相似文献

1
Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity.冷激活棕色脂肪组织与肥胖青年人群中心血管代谢功能障碍减少相关。
Obesity (Silver Spring). 2020 May;28(5):916-923. doi: 10.1002/oby.22767. Epub 2020 Mar 13.
2
Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts.与代谢不健康的肥胖人群相比，代谢健康的超重或肥胖成年人具有更多的棕色脂肪组织和更高的产热能力。
EBioMedicine. 2024 Feb;100:104948. doi: 10.1016/j.ebiom.2023.104948. Epub 2024 Jan 6.
3
Association of wrist and ambient temperature with cold-induced brown adipose tissue and skeletal muscle [F]FDG uptake in young adults.年轻人手腕温度和环境温度与冷诱导棕色脂肪组织和骨骼肌 [F]FDG 摄取的相关性。
Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1281-R1288. doi: 10.1152/ajpregu.00238.2018. Epub 2018 Oct 26.
4
Association between dietary factors and brown adipose tissue volume/F-FDG uptake in young adults.饮食因素与年轻成年人棕色脂肪组织体积/F-FDG 摄取量的相关性研究。
Clin Nutr. 2021 Apr;40(4):1997-2008. doi: 10.1016/j.clnu.2020.09.020. Epub 2020 Sep 19.
5
Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation.成纤维细胞生长因子 21、瘦素和脂联素对急性冷诱导棕色脂肪组织激活的反应。
J Clin Endocrinol Metab. 2020 Mar 1;105(3):e520-31. doi: 10.1210/clinem/dgaa005.
6
Cold-induced activity of brown adipose tissue in young lean men of South-Asian and European origin.南亚和欧洲裔年轻瘦男子棕色脂肪组织的冷诱导活性。
Diabetologia. 2013 Oct;56(10):2231-7. doi: 10.1007/s00125-013-2938-5. Epub 2013 Jun 25.
7
Repeatability of brown adipose tissue measurements on FDG PET/CT following a simple cooling procedure for BAT activation.经简单冷却程序激活 BAT 后，FDG PET/CT 中棕色脂肪组织测量的可重复性。
PLoS One. 2019 Apr 17;14(4):e0214765. doi: 10.1371/journal.pone.0214765. eCollection 2019.
8
Fecal microbiota composition is related to brown adipose tissue F-fluorodeoxyglucose uptake in young adults.粪便微生物组成与年轻成年人棕色脂肪组织 F-氟脱氧葡萄糖摄取有关。
J Endocrinol Invest. 2023 Mar;46(3):567-576. doi: 10.1007/s40618-022-01936-x. Epub 2022 Oct 15.
9
Sleep duration and quality are not associated with brown adipose tissue volume or activity-as determined by 18F-FDG uptake, in young, sedentary adults.在年轻、久坐的成年人中，睡眠持续时间和质量与棕色脂肪组织体积或活性（通过 18F-FDG 摄取来确定）无关。
Sleep. 2019 Dec 24;42(12). doi: 10.1093/sleep/zsz177.
10
Twelve weeks of exenatide treatment increases [F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males.十二周的 exenatide 治疗可增加棕色脂肪组织对 [F]氟脱氧葡萄糖的摄取，而不影响非糖尿病男性的氧化静息能量消耗。
Metabolism. 2020 May;106:154167. doi: 10.1016/j.metabol.2020.154167. Epub 2020 Jan 23.

引用本文的文献

1
Effect of tirzepatide-induced weight loss on adipose tissue in obesity: rationale and design of the randomized placebo-controlled Tirzepatide Brown and Beige Adipose Tissue Activation (TABFAT) trial.替尔泊肽诱导的体重减轻对肥胖患者脂肪组织的影响：随机安慰剂对照的替尔泊肽棕色和米色脂肪组织激活（TABFAT）试验的原理与设计
Trials. 2025 Aug 22;26(1):300. doi: 10.1186/s13063-025-09045-9.
2
Brown adipose tissue, anthropometric traits, and metabolic profiles in women with normal weight obesity.体重正常的肥胖女性的棕色脂肪组织、人体测量学特征和代谢概况。
Sci Rep. 2025 Jul 7;15(1):24194. doi: 10.1038/s41598-025-10583-0.
3
The Potential of Metabolomics as a Tool for Identifying Biomarkers Associated with Obesity and Its Complications: A Scoping Review.

本文引用的文献

1
Upper body fat predicts metabolic syndrome similarly in men and women.上半身脂肪对男性和女性代谢综合征的预测作用相似。
Eur J Clin Invest. 2018 Jul;48(7):e12941. doi: 10.1111/eci.12941. Epub 2018 May 15.
2
Leptin/adiponectin ratio in overweight patients - gender differences.超重患者的瘦素/脂联素比值——性别差异
Diab Vasc Dis Res. 2018 May;15(3):260-262. doi: 10.1177/1479164117752491. Epub 2018 Jan 10.
3
Loading and firing the brown adipocyte.加载并触发棕色脂肪细胞。
代谢组学作为识别与肥胖及其并发症相关生物标志物工具的潜力：一项范围综述
Int J Mol Sci. 2024 Dec 26;26(1):90. doi: 10.3390/ijms26010090.
4
Very-low-density lipoprotein triglyceride and free fatty acid plasma kinetics in women with high or low brown adipose tissue volume and overweight/obesity.高或低棕色脂肪组织体积及超重/肥胖女性极低密度脂蛋白甘油三酯和游离脂肪酸的血浆动力学。
Cell Rep Med. 2024 Jan 16;5(1):101370. doi: 10.1016/j.xcrm.2023.101370.
5
Brown Adipose Tissue: A New Potential Target for Glucagon-like Peptide 1 Receptor Agonists in the Treatment of Obesity.棕色脂肪组织：胰高血糖素样肽 1 受体激动剂治疗肥胖的新潜在靶点。
Int J Mol Sci. 2023 May 11;24(10):8592. doi: 10.3390/ijms24108592.
6
Fabricating 3-dimensional human brown adipose microtissues for transplantation studies.制造用于移植研究的三维人体棕色脂肪微组织。
Bioact Mater. 2022 Oct 27;22:518-534. doi: 10.1016/j.bioactmat.2022.10.022. eCollection 2023 Apr.
7
Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region.棕色脂肪甘油三酯含量与热带地区成年人的心血管风险标志物有关。
Front Endocrinol (Lausanne). 2022 Jul 19;13:919588. doi: 10.3389/fendo.2022.919588. eCollection 2022.
8
Influences of ovarian hormones on physiological responses to cold in women.卵巢激素对女性寒冷生理反应的影响。
Temperature (Austin). 2021 Sep 14;9(1):23-45. doi: 10.1080/23328940.2021.1953688. eCollection 2022.
9
Brown Adipose Tissue-A Translational Perspective.棕色脂肪组织——转化视角。
Endocr Rev. 2023 Mar 4;44(2):143-192. doi: 10.1210/endrev/bnac015.
10
Brown Adipose Tissue Prevalence Is Lower in Obesity but Its Metabolic Activity Is Intact.棕色脂肪组织在肥胖症中出现的概率较低，但它的代谢活性是完整的。
Front Endocrinol (Lausanne). 2022 Mar 31;13:858417. doi: 10.3389/fendo.2022.858417. eCollection 2022.
Adipocyte. 2018 Jan 2;7(1):4-11. doi: 10.1080/21623945.2017.1405879. Epub 2017 Dec 22.
4
Sildenafil induces browning of subcutaneous white adipose tissue in overweight adults.西地那非可诱导超重成年人皮下白色脂肪组织的褐色化。
Metabolism. 2018 Jan;78:106-117. doi: 10.1016/j.metabol.2017.09.008. Epub 2017 Oct 3.
5
Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men.寒冷诱导的棕色脂肪组织活性改变男性血浆脂肪酸并改善葡萄糖代谢。
J Clin Endocrinol Metab. 2017 Nov 1;102(11):4226-4234. doi: 10.1210/jc.2017-01250.
6
Human Brown Adipose Tissue Temperature and Fat Fraction Are Related to Its Metabolic Activity.人体棕色脂肪组织的温度和脂肪含量与其代谢活性相关。
J Clin Endocrinol Metab. 2017 Apr 1;102(4):1200-1207. doi: 10.1210/jc.2016-3086.
7
Quantification of brown and white adipose tissue based on Gaussian mixture model using water-fat and T2* MRI in adolescents.基于水脂和 T2*MRI 的高斯混合模型对青少年棕色和白色脂肪组织的定量研究。
J Magn Reson Imaging. 2017 Sep;46(3):758-768. doi: 10.1002/jmri.25632. Epub 2017 Jan 16.
8
Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.影像学研究中的棕色脂肪报告标准（BARCIST 1.0）：人体标准化氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描（FDG-PET/CT）实验的建议
Cell Metab. 2016 Aug 9;24(2):210-22. doi: 10.1016/j.cmet.2016.07.014.
9
Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans.在健康人体中，棕色脂肪组织参与饮食诱导产热和全身脂肪利用。
Int J Obes (Lond). 2016 Nov;40(11):1655-1661. doi: 10.1038/ijo.2016.124. Epub 2016 Jul 19.
10
Imaging of Brown Adipose Tissue: State of the Art.棕色脂肪组织的成像：当前技术水平
Radiology. 2016 Jul;280(1):4-19. doi: 10.1148/radiol.2016150390.