在结肠癌辅助化疗期间临床试验中，抗阻训练依从性报告的进展。
Advances in Adherence Reporting of Resistance Training in a Clinical Trial during Adjuvant Chemotherapy for Colon Cancer.
机构信息
University of British Columbia, Vancouver, British Columbia, CANADA.
Kaiser Permanente Northern California, Oakland, CA.
出版信息
Med Sci Sports Exerc. 2024 Jun 1;56(6):1186-1195. doi: 10.1249/MSS.0000000000003395. Epub 2024 Jan 17.
PURPOSE
Detailed reporting of individually tailored exercise prescriptions (ExR x ) used in clinical trials is essential to describe feasibility, tolerability, and efficacy of the intervention and to inform translation to clinical care. This article outlines the methodology used to develop a resistance training (RT) ExR x for people with colon cancer receiving chemotherapy and reports adherence to the randomized controlled trial testing the impact of RT on relative dose intensity of chemotherapy and patient-reported toxicities.
METHODS
Participants randomized to the exercise arm ( n = 90) were included. To promote muscle hypertrophy, the ExR x was twice-weekly, moderate to heavy loads (65%-85% one-repetition maximum), high sets (3-5), and intermediate repetitions (6-10) of five large multijoint movements with adjustable dumbbells. Attendance (achieved frequency) and adherence (achieved volume) were calculated. Group-based trajectory modeling was used to identify clusters of individuals with similar adherence patterns and compared baseline characteristics across adherence groups.
RESULTS
The median attendance was 69.1%. Adherence was 60.6% but higher for those receiving 3 versus 6 months of chemotherapy (80.4 vs 47.4%; P < 0.05 ). Participants engaged in a median of 1.4 d of RT each week, lifting 62% of the one-repetition maximum load, for 3.0 sets and 7.5 repetitions per set. Three distinct adherence groups were identified: 13% "nonstarter," 37% "tapered off," and 50% "consistent exercisers." Females were more likely to be in the nonstarter and tapered-off groups.
CONCLUSIONS
This article outlines suggested methods for reporting ExR x of RT in oncology clinical trials and provides insight into the tolerance of ExR x of RT during chemotherapy treatment for colon cancer. These findings aim to foster constructive dialogue and offer a premise for designing future research to elucidate the benefits of exercise during chemotherapy.
目的
详细报告临床试验中个体化运动处方（ExR x ）的使用情况对于描述干预措施的可行性、耐受性和疗效至关重要，并为将其转化为临床护理提供信息。本文概述了为接受化疗的结肠癌患者制定阻力训练（RT）ExR x 的方法，并报告了该方法在测试 RT 对化疗相对剂量强度和患者报告毒性影响的随机对照试验中的依从性。
方法
纳入了随机分配至运动组的 90 名参与者。为促进肌肉肥大，ExR x 为每周两次，使用中等至大负荷（65%-85%一次重复最大重量）、高组数（3-5 组）和中等重复次数（6-10 次）进行 5 个大多关节运动，使用可调节哑铃。计算了出勤率（实际频率）和依从率（实际运动量）。采用基于群组的轨迹建模来识别具有相似依从模式的个体群组，并比较不同依从群组的基线特征。
结果
中位出勤率为 69.1%。依从率为 60.6%，但接受 3 个月和 6 个月化疗的患者依从率更高（80.4%和 47.4%；P<0.05）。参与者每周平均进行 1.4 天的 RT，使用 62%的一次重复最大重量，每组 3.0 组，每组 7.5 次。确定了 3 个不同的依从群组：13%的“非起始者”、37%的“逐渐减少者”和 50%的“持续锻炼者”。女性更有可能属于非起始者和逐渐减少者群组。
结论
本文概述了在肿瘤学临床试验中报告 RT ExR x 的建议方法，并提供了关于在结肠癌化疗期间 RT ExR x 耐受性的见解。这些发现旨在促进建设性对话，并为设计未来的研究提供前提，以阐明化疗期间运动的益处。
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