Popkin Hall Zachary R, Seth Misago D, Madebe Rashid A, Budodo Rule, Bakari Catherine, Francis Filbert, Pereus Dativa, Giesbrecht David J, Mandara Celine I, Mbwambo Daniel, Aaron Sijenunu, Lusasi Abdallah, Lazaro Samwel, Bailey Jeffrey A, Juliano Jonathan J, Gutman Julie R, Ishengoma Deus S
Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
National Institute for Medical Research, Dar es Salaam, Tanzania.
medRxiv. 2023 Dec 30:2023.12.28.23300584. doi: 10.1101/2023.12.28.23300584.
Recent studies point to the need to incorporate non-falciparum species detection into malaria surveillance activities in sub-Saharan Africa, where 95% of malaria cases occur. Although infection is typically more severe, diagnosis, treatment, and control for , spp., and may be more challenging. The prevalence of these species throughout sub-Saharan Africa is poorly defined. Tanzania has geographically heterogeneous transmission levels but an overall high malaria burden. In order to estimate the prevalence of malaria species in Mainland Tanzania, 1,428 samples were randomly selected from 6,005 asymptomatic isolates collected in cross-sectional community surveys across four regions and analyzed via qPCR to detect each species. was most prevalent, with and spp. detected at lower prevalence (<5%) in all four regions. was not detected. Malaria elimination efforts in Tanzania will need to account for these non-falciparum species.
近期研究表明，在撒哈拉以南非洲地区（该地区发生了95%的疟疾病例），有必要将非恶性疟原虫种类的检测纳入疟疾监测活动。尽管感染通常更为严重，但对于间日疟原虫、卵形疟原虫和三日疟原虫的诊断、治疗和控制可能更具挑战性。这些疟原虫种类在整个撒哈拉以南非洲地区的流行情况界定不清。坦桑尼亚的疟疾传播水平在地理上存在差异，但总体疟疾负担较高。为了估计坦桑尼亚大陆疟原虫种类的流行情况，从四个地区的横断面社区调查收集的6005份无症状分离株中随机选取了1428份样本，并通过定量聚合酶链反应（qPCR）进行分析，以检测每种疟原虫种类。恶性疟原虫最为普遍，在所有四个地区中间日疟原虫和卵形疟原虫的检测率较低（<5%）。未检测到三日疟原虫。坦桑尼亚的疟疾消除工作需要考虑这些非恶性疟原虫种类。
