Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, SPH II, Room M5507, Ann Arbor, MI, 48109, USA.
Institute of Nutrition of Central America and Panama, INCAP Research Center for the Prevention of Chronic Diseases, Guatemala City, Guatemala.
Biol Trace Elem Res. 2024 Nov;202(11):4903-4908. doi: 10.1007/s12011-024-04069-9. Epub 2024 Jan 19.
The role of copper in the etiology of metabolic syndrome (MetS) is uncertain. We evaluated associations of plasma copper concentrations with MetS and its components in a cross-sectional study of 198 children ages 7-12 years and 378 adult parents from eight Mesoamerican countries. In children, the outcome was a metabolic risk score based on waist circumference, insulin resistance, mean arterial pressure (MAP), and blood lipids. In adults, we defined MetS per Adult Treatment Panel III criteria. Plasma copper was not significantly related to MetS in children or adults; however, children with copper above the median had a MAP score 0.04 (95% CI, 0.002, 0.08; P = 0.04) adjusted units higher and a HDL-cholesterol score 0.07 (95% CI, - 0.13, - 0.003; P = 0.04) adjusted units lower than those with lower copper concentrations. In adults, copper was positively related to abdominal obesity. Longitudinal studies to confirm the deleterious role of copper on MetS components are warranted.
铜在代谢综合征（MetS）发病机制中的作用尚不确定。我们在 8 个中美洲国家对 198 名 7-12 岁儿童和 378 名成年父母进行了一项横断面研究，评估了血浆铜浓度与 MetS 及其成分的相关性。在儿童中，结局是基于腰围、胰岛素抵抗、平均动脉压（MAP）和血脂的代谢风险评分。在成人中，我们根据成人治疗小组 III 标准定义了 MetS。铜与儿童或成人的 MetS 无显著相关性；然而，铜浓度处于中位数以上的儿童其 MAP 评分高 0.04 个单位（95%CI，0.002，0.08；P=0.04），HDL-胆固醇评分低 0.07 个单位（95%CI，-0.13，-0.003；P=0.04）。在成人中，铜与腹部肥胖呈正相关。需要进行纵向研究来证实铜对 MetS 成分的有害作用。
