Department of Pediatrics, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, China.
Medicine (Baltimore). 2024 Jan 19;103(3):e36862. doi: 10.1097/MD.0000000000036862.
To explore the relationship between specific immunoglobulin E levels in response to prevalent pollen and food allergens among patients suffering from localized allergic diseases in the Dongying area of China, and to analyze the interconnectivity among these factors.
This research encompassed allergic patients who visited the Allergy Department of Shengli Oilfield Central Hospital from January 2022 to January 2023. We examined the specific immunoglobulin E levels in the blood of 230 patients utilizing the Fobock platform provided by Jiangsu Haoeubo Company. Statistical analysis was conducted with SPSS 25.0 statistical software. The chi-square test evaluated the relevance of differences in gender and age. A value of P < .05 was considered statistically significant.
In this study, eggs emerged as the allergen with the highest number of sensitized individuals, closely followed by dust mite. Conversely, the least sensitized allergen was the cypress tree, closely followed by mango. Notably, male patients exhibited higher sensitivities to cottonwood (P < .05) and egg (P < .001) compared to female patients. Children aged 0 to 10 years showed increased sensitivity to variety of allergens. A significant correlation was observed among different allergens. The top ten allergen pairs with the highest correlation included Birch Tree and Cottonwood (0.88, P < .001), Cottonwood and Pine Tree (0.86, P < .001), Birch Tree and Pine Tree (0.84, P < .001), Pine Tree and Paulownia (0.81, P < .001), Dust Mite and House Dust Mite (0.76, P < .001), Birch Tree and Paulownia (0.73, P < .001), Cashew and Pistachio (0.71, P < .001), Apple and Hazelnut (0.71, P < .001), Cottonwood and Paulownia (0.71, P < .001), and Pine Tree and Ordinary Ragweed (0.70, P < .001).
This research sheds light on the patterns of allergen sensitization in Dongying, Shandong, highlighting that egg is the most prevalent sensitizing allergen. A notably high correlation was observed between Birch Tree and Cottonwood. This study enhanced the understanding of allergic diseases, explored the causes and mechanisms of allergies, strengthened the management of allergic diseases. Furthermore, it offers valuable insights for the clinical diagnosis and prevention of allergic diseases.
本研究旨在探讨中国东营地区局部过敏性疾病患者对流行花粉和食物过敏原的特异性免疫球蛋白 E 水平之间的关系，并分析这些因素之间的相互关系。
本研究纳入了 2022 年 1 月至 2023 年 1 月期间就诊于胜利油田中心医院过敏科的过敏性患者。我们使用江苏浩欧博公司提供的 Fobock 平台检测了 230 名患者的血液特异性免疫球蛋白 E 水平。采用 SPSS 25.0 统计软件进行统计学分析。卡方检验评估了性别和年龄差异的相关性。P 值<.05 被认为具有统计学意义。
在这项研究中，鸡蛋是致敏人数最多的过敏原，紧随其后的是尘螨。相反，致敏性最低的过敏原是柏树，紧随其后的是芒果。值得注意的是，与女性患者相比，男性患者对杨属（P<.05）和鸡蛋（P<.001）的敏感性更高。0 至 10 岁的儿童对多种过敏原的敏感性增加。不同过敏原之间存在显著相关性。相关性最高的前十大过敏原对包括桦树和杨属（0.88，P<.001）、杨属和松树（0.86，P<.001）、桦树和松树（0.84，P<.001）、松树和泡桐（0.81，P<.001）、尘螨和屋尘螨（0.76，P<.001）、桦树和泡桐（0.73，P<.001）、腰果和开心果（0.71，P<.001）、苹果和榛子（0.71，P<.001）、杨属和泡桐（0.71，P<.001）以及松树和普通豚草（0.70，P<.001）。
本研究揭示了山东东营地区过敏原致敏模式，表明鸡蛋是最常见的致敏过敏原。桦树和杨属之间存在显著的高相关性。本研究加深了对过敏性疾病的认识，探讨了过敏的原因和机制，加强了过敏性疾病的管理。此外，它为过敏性疾病的临床诊断和预防提供了有价值的见解。
