Sacchini V, Melloni E, Marchesini R, Fabrizio T, Cascinelli N, Santoro O, Zunino F, Andreola S, Bandieramonte G
Tumori. 1987 Feb 28;73(1):19-23. doi: 10.1177/030089168707300103.
In photodynamic therapy, systemic administration of photosensitizing agents induces cutaneous photosensitization in patients. This side-effect can be avoided by topical administration of the agents when only surface lesions are involved. A hydroalcoholic solution of tetrasodium-meso-tetraphenylporphinesulfonate (TPPS) containing Azone, a percutaneous penetration enhancer, was investigated to evaluate its photosensitizing potential in the treatment of 33 primary and recurrent neoplastic lesions of the skin. A complete remission was obtained of lesions with clinical thickness of less than 2 mm. Treatment effectiveness depends on both light and drug penetration through skin. Further studies are in progress to optimize treatment parameters.
在光动力疗法中，向患者全身给药光敏剂会引发皮肤光过敏。当仅涉及体表病变时，通过局部给药可避免这种副作用。研究了一种含有透皮促进剂氮酮的中-四苯基卟啉磺酸钠（TPPS）的水醇溶液，以评估其在治疗33例原发性和复发性皮肤肿瘤性病变中的光敏潜力。对于临床厚度小于2毫米的病变，实现了完全缓解。治疗效果取决于光和药物透过皮肤的程度。目前正在进行进一步研究以优化治疗参数。
