Stocchi V, Canestrari F, Giacchi R, Sebastiani M, Lungarotti F, Dachà U, Dachà M
Tumori. 1987 Feb 28;73(1):25-8. doi: 10.1177/030089168707300104.
The concentration of adenine (ATP, ADP, AMP) and pyridine (NADP+, NADPH, NAD+, NADH) nucleotides in the erythrocytes of subjects affected by solid tumors was evaluated using a method which allows their simultaneous extraction and reverse-phase high-performance liquid chromatographic analysis. The results showed a lower level of ATP in the erythrocytes of subjects affected by solid tumors, whereas no significant modifications were observed in the other compounds. In fact, the mean value of ATP in these subjects was 27% lower than that of normal adults. This fact is discussed in relation to other enzymatic and metabolic modifications previously observed in red blood cells.
采用一种可同时提取并进行反相高效液相色谱分析的方法，对实体瘤患者红细胞中腺嘌呤（ATP、ADP、AMP）和吡啶（NADP⁺、NADPH、NAD⁺、NADH）核苷酸的浓度进行了评估。结果显示，实体瘤患者红细胞中的ATP水平较低，而其他化合物未观察到明显变化。事实上，这些患者的ATP平均值比正常成年人低27%。结合先前在红细胞中观察到的其他酶促和代谢变化对这一事实进行了讨论。
