Hertie Institute for Clinical Brain Research, Center for Neurology, University Medical Center Tübingen, Tübingen, Germany.
International Max Planck Research School for the Mechanisms of Mental Function and Dysfunction, University of Tübingen, Tübingen, Germany.
Nat Commun. 2024 Jan 20;15(1):637. doi: 10.1038/s41467-023-44571-7.
Contextual cues and prior evidence guide human goal-directed behavior. The neurophysiological mechanisms that implement contextual priors to guide subsequent actions in the human brain remain unclear. Using intracranial electroencephalography (iEEG), we demonstrate that increasing uncertainty introduces a shift from a purely oscillatory to a mixed processing regime with an additional ramping component. Oscillatory and ramping dynamics reflect dissociable signatures, which likely differentially contribute to the encoding and transfer of different cognitive variables in a cue-guided motor task. The results support the idea that prefrontal activity encodes rules and ensuing actions in distinct coding subspaces, while theta oscillations synchronize the prefrontal-motor network, possibly to guide action execution. Collectively, our results reveal how two key features of large-scale neural population activity, namely continuous ramping dynamics and oscillatory synchrony, jointly support rule-guided human behavior.
上下文线索和先前的证据指导人类有目标的行为。在人类大脑中，实现上下文优先以指导后续行动的神经生理机制仍不清楚。使用颅内脑电图（iEEG），我们证明，增加不确定性会导致从纯粹的振荡转变为混合处理模式，并增加一个斜坡组件。振荡和斜坡动力学反映了可分离的特征，这可能对在线索引导的运动任务中编码和传递不同的认知变量有不同的贡献。研究结果支持这样一种观点，即前额叶活动以不同的编码子空间编码规则和随后的动作，而θ振荡同步前额叶-运动网络，可能以指导动作执行。总的来说，我们的研究结果揭示了大规模神经群体活动的两个关键特征，即连续斜坡动力学和振荡同步性，如何共同支持规则指导的人类行为。
Zotero 插件
