在情节记忆检索过程中前馈预测误差信号。
Feedforward prediction error signals during episodic memory retrieval.
机构信息
Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, 20892, USA.
Office of the Clinical Director, NINDS, National Institutes of Health, Bethesda, MD, 20892, USA.
出版信息
Nat Commun. 2020 Nov 27;11(1):6075. doi: 10.1038/s41467-020-19828-0.
Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for future experience within neocortical-medial temporal lobe circuits. When subsequent experiences violate these expectations, we find a 80-120 Hz prediction error signal that emerges in both visual association areas and the medial temporal lobe. Critically, this error signal emerges in visual association areas first and then propagates to the medial temporal lobe. This error signal is accompanied by alpha coherence between the two regions. Our data therefore suggest that internal models formed from episodic memories are generated throughout the visual hierarchy after just a single exposure, and that these internal models are then used for comparison with future experiences.
我们的记忆使我们能够对未来的经验产生期望，但我们将任何经验与记忆进行比较的确切神经机制尚不清楚。在这里，我们使用颅内 EEG 记录显示，单次视觉体验后形成的情景记忆会在新皮质-内侧颞叶回路中建立对未来经验的期望。当随后的经验违反这些期望时，我们发现了一个 80-120 Hz 的预测误差信号，它出现在视觉联合区和内侧颞叶中。关键的是，这个误差信号首先出现在视觉联合区，然后传播到内侧颞叶。这个误差信号伴随着两个区域之间的 alpha 相干性。因此，我们的数据表明，单次暴露后，从情景记忆中形成的内部模型会在整个视觉层次结构中生成，然后这些内部模型会被用于与未来经验进行比较。
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