Marine College, Shandong University, Weihai 264209, China.
Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai 264299, China.
Carbohydr Polym. 2023 Apr 1;305:120545. doi: 10.1016/j.carbpol.2023.120545. Epub 2023 Jan 7.
Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through the reduction of Ag with tannic acid (TA) as a reducing agent. The CS/CA/Ag cryogel has good mechanical properties and interconnected macroporous structures. The results of hemostasis tests show that CS/CA/Ag cryogel can absorb a large amount of blood and promote blood cell adhesion compared with commercial gelatin sponges and gauze. Meanwhile, CS/CA/Ag cryogel has a good antibacterial ability against S. aureus and E. coli. Furthermore, CS/CA/Ag cryogel significantly promotes wound healing in the full-thickness wound model infected with S. aureus. In conclusion, the cryogel prepared by the simple method has great advantages in rapid hemostasis and promoting wound healing.
大面积的皮肤损伤可能会导致大量出血和潜在的伤口感染。因此，通过简单的方法制备满足这些要求的低成本伤口敷料具有很好的应用前景。在本研究中，通过混合壳聚糖（CS）和柠檬酸（CA）在低温下制备形状记忆水凝胶。通过用单宁酸（TA）作为还原剂将银还原到水凝胶中引入了银纳米粒子（Ag NPs）。CS/CA/Ag 水凝胶具有良好的机械性能和相互连通的大孔结构。止血测试的结果表明，与商业明胶海绵和纱布相比，CS/CA/Ag 水凝胶可以吸收大量血液并促进血细胞黏附。同时，CS/CA/Ag 水凝胶对金黄色葡萄球菌和大肠杆菌具有良好的抗菌能力。此外，CS/CA/Ag 水凝胶在金黄色葡萄球菌感染的全层伤口模型中显著促进了伤口愈合。总之，通过简单方法制备的水凝胶在快速止血和促进伤口愈合方面具有很大的优势。
