Research Group, Department of Neurology, Schoen Clinic Bad Aibling, 83043 Bad Aibling, Germany.
Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, 81377 Munich, Germany.
Int J Environ Res Public Health. 2023 Dec 22;21(1):21. doi: 10.3390/ijerph21010021.
Severe acute COVID-19 infections requiring intensive care treatment are reported risk factors for the development of post-COVID-19 conditions. However, there are also individuals suffering from post-COVID-19 symptoms after mild infections. Therefore, we aimed to describe and compare the health status of patients who were initially not hospitalized and patients after critical illness due to COVID-19. The outcome measures included health-related quality of life (EQ-5D-5L, visual analogue scale (VAS)); mental health (hospital anxiety and depression scale (HADS)); general disability (WHODAS-12); and fatigue (Fatigue-Severity-Scale-7). Individuals were recruited at Schoen Clinic Bad Aibling, Germany. A total of 52 non-hospitalized individuals (47 ± 15 years, 64% female, median 214 days post-infection) and 75 hospitalized individuals (61 ± 12 years, 29% female, 235 days post-infection) were analyzed. The non-hospitalized individuals had more fatigue (87%) and anxiety (69%) and a decreased health-related quality of life (VAS 47 ± 20) compared to the hospitalized persons (fatigue 45%, anxiety 43%, VAS 57 ± 21; < 0.010). Severe disability was observed in one third of each group. A decreased quality of life and disability were more pronounced in the females of both groups. After adjusting for confounding, hospitalization did not predict the burden of symptoms. This indicates that persons with post-COVID-19 conditions require follow-up services and treatments, independent of the severity of the acute infection.
严重的急性 COVID-19 感染需要重症监护治疗，据报道这是发生新冠后疾病的危险因素。然而，也有一些人在轻度感染后出现新冠后症状。因此，我们旨在描述和比较最初未住院和因 COVID-19 而患重病的患者的健康状况。结局指标包括健康相关的生活质量（EQ-5D-5L，视觉模拟量表（VAS））；心理健康（医院焦虑和抑郁量表（HADS））；一般残疾（WHO-DAS-12）；疲劳（疲劳严重程度量表-7）。个体在德国巴德阿伊灵的舍恩诊所招募。共分析了 52 名未住院的个体（47 ± 15 岁，64%为女性，感染后中位数 214 天）和 75 名住院的个体（61 ± 12 岁，29%为女性，感染后中位数 235 天）。与住院患者相比，未住院患者的疲劳（87%）和焦虑（69%）更多，健康相关生活质量较低（VAS 47 ± 20）（疲劳 45%，焦虑 43%，VAS 57 ± 21；<0.010）。两组各有三分之一的患者存在严重残疾。两组女性的生活质量和残疾程度下降更为明显。在调整混杂因素后，住院并不能预测症状负担。这表明，无论急性感染的严重程度如何，患有新冠后疾病的患者都需要接受后续的服务和治疗。
