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从 sp. SNC087 菌株中分离出的星形孢菌素对鼻息肉的抑制作用及机制。

The Inhibition Effect and Mechanism of Staurosporine Isolated from sp. SNC087 Strain on Nasal Polyp.

机构信息

Department of Microbial Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Republic of Korea.

Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.

出版信息

Mar Drugs. 2024 Jan 11;22(1):39. doi: 10.3390/md22010039.

DOI:10.3390/md22010039
PMID:38248664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10820969/
Abstract

This study aims to explore the potential inhibition effects of staurosporine isolated from a sp. SNC087 strain obtained from seawater on nasal polyps. Staurosporine possesses antimicrobial and antihypertensive activities. This research focuses on investigating the effects of staurosporine on suppressing the growth and development of nasal polyps and elucidating the underlying mechanisms involved. The experimental design includes in vitro and ex vivo evaluations to assess the inhibition activity and therapeutic potential of staurosporine against nasal polyps. Nasal polyp-derived fibroblasts (NPDFs) were stimulated with TGF-β1 in the presence of staurosporine. The levels of α-smooth muscle actin (α-SMA), collagen type-I (Col-1), fibronectin, and phosphorylated (p)-Smad 2 were investigated using Western blotting. VEGF expression levels were analyzed in nasal polyp organ cultures treated with staurosporine. TGF-β1 stimulated the production of Col-1, fibronectin, and α-SMA and was attenuated by staurosporine pretreatment. Furthermore, these inhibitory effects were mediated by modulation of the signaling pathway of Smad 2 in TGF-β1-induced NPDFs. Staurosporine also inhibits the production of VEGF in ex vivo NP tissues. The findings from this study will contribute to a better understanding of staurosporine's role in nasal polyp management and provide insights into its mechanisms of action.

摘要

本研究旨在探索来源于海水 sp. SNC087 菌株的星形孢菌素对鼻息肉的潜在抑制作用。星形孢菌素具有抗菌和降压活性。本研究重点研究星形孢菌素抑制鼻息肉生长和发育的作用，并阐明其相关机制。实验设计包括体外和离体评估，以评估星形孢菌素对鼻息肉的抑制活性和治疗潜力。鼻息肉衍生成纤维细胞（NPDFs）在存在星形孢菌素的情况下用 TGF-β1 刺激。使用 Western blot 法检测α-平滑肌肌动蛋白（α-SMA）、I 型胶原（Col-1）、纤维连接蛋白和磷酸化（p）-Smad 2 的水平。用星形孢菌素处理鼻息肉器官培养物以分析 VEGF 表达水平。TGF-β1 刺激 Col-1、纤维连接蛋白和 α-SMA 的产生，星形孢菌素预处理可减弱其产生。此外，这些抑制作用是通过调节 TGF-β1 诱导的 NPDFs 中 Smad 2 信号通路来介导的。星形孢菌素还抑制离体 NP 组织中 VEGF 的产生。本研究的结果将有助于更好地了解星形孢菌素在鼻息肉管理中的作用，并深入了解其作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/03362b5812a2/marinedrugs-22-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/469ab610f85a/marinedrugs-22-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/d7ab76ece93b/marinedrugs-22-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/235c4d84bea5/marinedrugs-22-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/baff712018f3/marinedrugs-22-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/03362b5812a2/marinedrugs-22-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/469ab610f85a/marinedrugs-22-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/d7ab76ece93b/marinedrugs-22-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/235c4d84bea5/marinedrugs-22-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/baff712018f3/marinedrugs-22-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/10820969/03362b5812a2/marinedrugs-22-00039-g005.jpg

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The Inhibition Effect and Mechanism of Staurosporine Isolated from sp. SNC087 Strain on Nasal Polyp.

Mar Drugs. 2024-1-11

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[6]
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[8]
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[9]
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本文引用的文献

[1]
TGF-β signaling in health and disease.

Cell. 2023-9-14

[2]
Pathogenesis of Nasal Polyposis: Current Trends.

Indian J Otolaryngol Head Neck Surg. 2023-4

[3]
Therapeutic Strategies to Prevent the Recurrence of Nasal Polyps after Surgical Treatment: An Update and In Vitro Study on Growth Inhibition of Fibroblasts.

J Clin Med. 2023-4-13

[4]
Antifibrosis Efficacy of Apo-9-Fucoxanthinone-Contained Ethanol Extract on Nasal Polyp: An In Vitro and Ex Vivo Organ Culture Assay.

Curr Issues Mol Biol. 2022-11-21

[5]
Role of fibroblasts in wound healing and tissue remodeling on Earth and in space.

Front Bioeng Biotechnol. 2022-10-4

[6]
Cytotoxic Indolocarbazoles From a Marine-Derived Sp. OUCMDZ-5380.

Front Microbiol. 2022-7-12

[7]
Transforming growth factor beta induces fibroblasts to express and release the immunomodulatory protein PD-L1 into extracellular vesicles.

FASEB J. 2019-12-12

[8]
Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis.

Arthritis Res Ther. 2019-12-21

[9]
Tissue remodelling in chronic rhinosinusitis - review of literature.

Otolaryngol Pol. 2019-9-2

[10]
Eosinophil extracellular trap formation is closely associated with disease severity in chronic rhinosinusitis regardless of nasal polyp status.

Sci Rep. 2019-5-30

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