Cui Tongxu, Lin Simin, Wang Zizhen, Fu Peng, Wang Cong, Zhu Weiming
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Front Microbiol. 2022 Jul 12;13:957473. doi: 10.3389/fmicb.2022.957473. eCollection 2022.
Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F-H (-), along with staurosporine () were isolated from the marine-derived sp. OUCMDZ-5380. Structures of streptocarbazoles F-H were, respectively, determined as -demethyl--hexanoylstaurosporine (), -demethyl--(2-methyl-3-methoxypyridin-4-yl) staurosporine staurosporine (), and 4-(-demethylstaurosporine--yl)-1,2-dimethyl-3-methoxypyridinium () by spectroscopic analysis and electronic circular dichroism comparison with staurosporine. Compared with staurosporine (), streptocarbazoles F-H (-) showed a selective antiproliferation of the acute myeloid leukemia cell line MV4-11 with the IC values of 0.81, 0.55, and 1.88 μM, respectively.
在全球天然产物社会分子网络的指导下，从海洋来源的链霉菌属OUCMDZ - 5380中分离出三种新的吲哚咔唑，命名为链霉咔唑F - H（-），以及星形孢菌素（）。通过光谱分析和与星形孢菌素的电子圆二色性比较，分别确定链霉咔唑F - H的结构为 - 去甲基 - - 己酰基星形孢菌素（）、 - 去甲基 - - （2 - 甲基 - 3 - 甲氧基吡啶 - 4 - 基）星形孢菌素星形孢菌素（）和4 - （ - 去甲基星形孢菌素 - - 基） - 1,2 - 二甲基 - 3 - 甲氧基吡啶鎓（）。与星形孢菌素（）相比，链霉咔唑F - H（-）对急性髓性白血病细胞系MV4 - 11表现出选择性抗增殖作用，IC值分别为0.81、0.55和1.88 μM。
