Dondi Francesco, Pisani Antonio Rosario, Lucarelli Nicola Maria, Gazzilli Maria, Talin Anna, Albano Domenico, Rubini Dino, Maggialetti Nicola, Rubini Giuseppe, Bertagna Francesco
Nuclear Medicine, Università Degli Studi di Brescia and ASST Spedali Civili Brescia, 25123 Brescia, Italy.
Section of Nuclear Medicine, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.
J Pers Med. 2023 Dec 28;14(1):40. doi: 10.3390/jpm14010040.
Different insights into the connection between kidney [F]fluorodesoxyglucose ([F]FDG) uptake at positron emission tomography/computed tomography (PET/CT) and renal function have been proposed in the past. The aim of this study was therefore to assess the presence of a correlation between these two parameters. Kidney uptakes were assessed and compared to the creatinine (Cr) values and estimated glomerular filtration rate (EGFR) among different classes of renal functional impairment or kidney status. A total of 339 patients and 385 different PET/CT scans were included in this study. Significant correlations between kidney uptakes and renal function parameters were reported in most of the groups studied, with the exception of patients with Cr < 1.2 mg/dL and subjects with a kidney transplantation. Strong concordance in the assessment of renal parenchymal uptakes between the different readers was reported. To conclude, strong correlations for renal [F]FDG uptake with Cr levels and the EGFR were reported, with the exception of the group of patients with a Cr value < 1.2 mg/dL and for the group with a kidney transplantation.
过去人们对正电子发射断层扫描/计算机断层扫描（PET/CT）时肾脏[F]氟脱氧葡萄糖（[F]FDG）摄取与肾功能之间的联系有不同见解。因此，本研究的目的是评估这两个参数之间是否存在相关性。在不同程度的肾功能损害或肾脏状态类别中，评估肾脏摄取情况，并与肌酐（Cr）值和估计肾小球滤过率（EGFR）进行比较。本研究共纳入339例患者和385次不同的PET/CT扫描。在所研究的大多数组中，均报告了肾脏摄取与肾功能参数之间存在显著相关性，但Cr<1.2mg/dL的患者和接受肾脏移植的受试者除外。不同阅片者对肾实质摄取的评估结果具有高度一致性。总之，除了Cr值<1.2mg/dL的患者组和肾脏移植组外，报告显示肾脏[F]FDG摄取与Cr水平和EGFR之间存在强相关性。
