Department of Radiology, Tokushima University, Tokushima City, Japan.
Department of Radiology, Nagoya University Hospital, Nagoya City, Japan.
Nucl Med Rev Cent East Eur. 2022;25(2):95-100. doi: 10.5603/NMR.a2022.0021. Epub 2022 Jul 18.
In the daily clinical course, the liver uptake may seem to be increased in patients with renal failure. The purpose of this study was to investigate whether or not the FDG uptake of the liver, and the FDG uptake of blood pool which is generally used as a reference site as well as liver, is increased in patients with renal failure.
We retrospectively analyzed 233 patients who underwent FDG positron emission tomography/computed tomography (PET/CT). Renal failure is defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. We compared the FDG uptake in the liver and mediastinal blood pool of 67 patients with impaired renal function to that in 166 patients with a normal renal function (eGFR ≥ 60 mL/min/1.73 m2). Correlations between the liver or mediastinal blood pool FDG uptake and the eGFR were also analyzed by Spearman's correlation test.
Maximum and mean standardized uptake values (SUVmax and SUVmean, respectively) of the liver and the SUVmean of the mediastinal blood pool were 3.48 ± 0.57, 2.56 ± 0.37, and 1.90 ± 0.28 in the impaired renal function group, respectively, and 3.13 ± 0.45, 2.29 ± 0.33, and 1.66 ± 0.23, in the normal group, respectively. The SUVmax and SUVmean of the liver and SUVmean of the mediastinal blood pool in the impaired renal function group were significantly higher than those in the normal group (p < 0.001, < 0.001, and < 0.001, respectively). The SUVmax and SUVmean of the liver and SUVmean of the mediastinal blood pool of patients showed a significant negative correlation with the eGFR (Spearman's p = -0.25, -0.30, and -0.40, respectively, each p < 0.001).
FDG uptake in both the liver and mediastinal blood pool was higher in patients with impaired renal function.
在日常临床过程中，肾功能衰竭患者的肝脏摄取似乎增加。本研究旨在探讨肾功能衰竭患者的肝脏 FDG 摄取以及通常用作参考部位的血池 FDG 摄取是否增加。
我们回顾性分析了 233 例接受 FDG 正电子发射断层扫描/计算机断层扫描（PET/CT）的患者。肾功能衰竭定义为估算肾小球滤过率（eGFR）<60 mL/min/1.73 m2。我们比较了 67 例肾功能受损患者和 166 例肾功能正常患者（eGFR≥60 mL/min/1.73 m2）的肝脏和纵隔血池 FDG 摄取。还通过 Spearman 相关检验分析了肝脏或纵隔血池 FDG 摄取与 eGFR 之间的相关性。
肾功能受损组肝脏和纵隔血池的最大标准化摄取值（SUVmax 和 SUVmean）分别为 3.48 ± 0.57、2.56 ± 0.37 和 1.90 ± 0.28，正常组分别为 3.13 ± 0.45、2.29 ± 0.33 和 1.66 ± 0.23。肾功能受损组肝脏和纵隔血池的 SUVmax 和 SUVmean 以及纵隔血池的 SUVmean 均显著高于正常组（p<0.001、<0.001 和<0.001）。患者肝脏和纵隔血池的 SUVmax 和 SUVmean 与 eGFR 呈显著负相关（Spearman p=-0.25、-0.30 和-0.40，均 p<0.001）。
肾功能受损患者的肝脏和纵隔血池 FDG 摄取均升高。
