Lachowicz J I, Nurchi V M, Fanni D, Gerosa C, Peana M, Zoroddu M A
Dipartimento di Scienze Chimiche e Geologiche, University of Cagliari, Cittadella Universitaria, I- 09042 Monserrato, Italy.
Curr Med Chem. 2014;21(33):3775-84. doi: 10.2174/0929867321666140706143925.
Nutritional iron deficiency represents a relevant health problem mainly in developing countries. Children and pregnant women represent the main target of this disease, and the low amount of bio-available iron mostly depends on plant-based diets. Iron deficiency may have serious consequences, with severe impairment of the immune function leading to infectious diseases. The brain development in embryos and fetuses during gestation can be greatly affected by iron deficiency of the mother with heavy outcomes on the cognition status of children. A better understanding of molecular pathways involved in iron absorption and metabolism are the basis for new strategies for developing a therapy for iron deficiency. Different therapeutic strategies are summarized, and iron fortification appears the best tool.
营养性缺铁主要是发展中国家的一个相关健康问题。儿童和孕妇是这种疾病的主要目标人群，生物可利用铁含量低主要取决于以植物性食物为主的饮食。缺铁可能会产生严重后果，免疫功能严重受损会导致传染病。孕期胚胎和胎儿的大脑发育会受到母亲缺铁的极大影响，对儿童的认知状况会产生严重后果。更好地了解铁吸收和代谢所涉及的分子途径是开发缺铁治疗新策略的基础。本文总结了不同的治疗策略，铁强化似乎是最佳手段。
