Confavreux C, Caudie C, Touraine F, Ventre J J, Aimard G, Devic M
Acta Neurol Scand. 1986 Dec;74(6):432-8. doi: 10.1111/j.1600-0404.1986.tb07868.x.
Cerebrospinal fluid (CSF) cytocentrifugation was performed for plasma cells' demonstration in parallel with white cell count (WCC) and quantitative protein assays. Over a 5-year period, 154 consecutive multiple sclerosis (MS) patients were studied and compared to 28 other inflammatory neurological disease, 85 non-inflammatory neurological disease and 29 non-neurological disease cases. CSF cytology was easy to perform, gave definitive results within 2 h and was abnormal in 80 MS patients, 26 of whom had a normal WCC. Its sensitivity in MS was 0.57, i.e. higher than for WCC (0.45) but lower than for IgG index (0.70) and IgG synthesis rate (0.71). Its specificity was 0.86, not significantly different from specificity of WCC, IgG index and IgG synthesis rate. Plasma cells demonstration in MS CSF was neither a disease activity nor a prognosis marker. It was significantly correlated with pleiocytosis and intrathecal IgG synthesis. If these morphologically defined plasma cells are actual B cells, they could represent circulating individuals of the lymphocyte clones active in MS plaques and have a pathogenetic significance.
进行脑脊液（CSF）细胞离心以显示浆细胞，同时进行白细胞计数（WCC）和定量蛋白测定。在5年期间，对154例连续的多发性硬化症（MS）患者进行了研究，并与28例其他炎性神经系统疾病、85例非炎性神经系统疾病和29例非神经系统疾病病例进行了比较。脑脊液细胞学检查操作简便，2小时内即可得出明确结果，80例MS患者结果异常，其中26例白细胞计数正常。其在MS中的敏感性为0.57，即高于白细胞计数（0.45），但低于IgG指数（0.70）和IgG合成率（0.71）。其特异性为0.86，与白细胞计数、IgG指数和IgG合成率的特异性无显著差异。MS脑脊液中浆细胞的显示既不是疾病活动的标志物，也不是预后的标志物。它与细胞增多症和鞘内IgG合成显著相关。如果这些形态学上定义的浆细胞实际上是B细胞，它们可能代表在MS斑块中活跃的淋巴细胞克隆的循环个体，并具有致病意义。
