多发性硬化症患者脑脊液中IgG寡克隆带的间断分布。

Discontinuous distribution of IgG oligoclonal bands in cerebrospinal fluid from multiple sclerosis patients.

作者信息

Martino G, Grimaldi L M, Moiola L, Filippi M, Martinelli V, Comi G, Canal N

机构信息

Clinica Neurologica IV, Università di Milano, IRCCS, H. San Raffaele, Italy.

出版信息

J Neuroimmunol. 1990 Dec;30(2-3):129-34. doi: 10.1016/0165-5728(90)90096-6.

DOI:10.1016/0165-5728(90)90096-6

PMID:2229406

Abstract

To test the effect of sampling on the detection of immunoglobulin (Ig) cerebrospinal fluid (CSF) abnormalities, we analyzed the first and last 1 ml fraction of 10 ml obtained during a single CSF removal from 27 multiple sclerosis (MS) patients and six patients with other neurological diseases. IgG index, hyperbolic function, and IgG synthesis rate decreased between the first and the last CSF aliquot. Discordant results were found in 4/27 (15%) MS patients. In 2/27 (7.5%) clinically definite MS patients, the number of CSF oligoclonal bands (OCB) decreased between the first and the last fraction. In one of the two patients, the three OCB visualized in the first fraction were not found in the last. We conclude that fractionated sampling may partially account for the absence of OCB in the CSF of some definite MS patients.

摘要

为测试采样对免疫球蛋白（Ig）脑脊液（CSF）异常检测的影响，我们分析了从27例多发性硬化症（MS）患者和6例其他神经系统疾病患者单次采集脑脊液过程中获得的10毫升脑脊液的首末1毫升部分。首末脑脊液样本之间的IgG指数、双曲线函数和IgG合成率均下降。在27例MS患者中有4例（15%）出现结果不一致的情况。在27例临床确诊的MS患者中有2例（7.5%），脑脊液寡克隆带（OCB）数量在首末样本之间减少。在这两名患者中的一名患者中，首份样本中可见的三条OCB在末份样本中未被发现。我们得出结论，分段采样可能部分解释了一些确诊MS患者脑脊液中OCB缺失的原因。