重症肌无力中的血浆置换：对抗乙酰胆碱受体抗体及其他自身抗体的影响

Plasma exchange in myasthenia gravis: effect on anti-AChR antibodies and other autoantibodies.

作者信息

Thorlacius S, Lefvert A K, Aarli J A, Gilhus N E, Halvorsen K, Hofstad H, Matre R, Tönder O

出版信息

Acta Neurol Scand. 1986 Dec;74(6):486-90. doi: 10.1111/j.1600-0404.1986.tb07875.x.

DOI:10.1111/j.1600-0404.1986.tb07875.x

Abstract

Plasma exchange (PE) was performed in 6 patients with myasthenia gravis (MG). Acetylcholine receptor (AChR) antibodies and other MG-correlated antibodies were quantified each day before, during and after PE. The antibody concentrations decreased during PE with a consisting increase between two exchanges. Repeated PE induced a transient decline in the AChR antibody concentration. The clinical improvement was maximal during the week after PE and correlated in time with increasing concentrations of AChR antibodies.

摘要

对6例重症肌无力（MG）患者进行了血浆置换（PE）。在血浆置换前、置换期间和置换后每天对乙酰胆碱受体（AChR）抗体和其他与重症肌无力相关的抗体进行定量。在血浆置换期间抗体浓度下降，两次置换之间持续增加。重复进行血浆置换导致AChR抗体浓度短暂下降。临床改善在血浆置换后的一周内最为明显，并且在时间上与AChR抗体浓度的增加相关。