Guo Qihao, Yang Shuoshuo, Ni Guoqi, Ji Jiale, Luo Mengwei, Du Wei
Key Laboratory of Textile Fiber and Products, Wuhan Textile University, Ministry of Education, Wuhan 430200, China.
State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan 430073, China.
Biomedicines. 2023 Dec 27;12(1):70. doi: 10.3390/biomedicines12010070.
Reactive oxygen species (ROS) has great influence in many physiological or pathological processes in organisms. In the site of bone defects, the overproduced ROS significantly affects the dynamic balance process of bone regeneration. Many antioxidative organic and inorganic antioxidants showed good osteogenic ability, which has been widely used for bone repair. It is of great significance to summarize the antioxidative bone repair materials (ABRMs) to provide guidance for the future design and preparation of osteogenic materials with antioxidative function. Here, this review introduced the major research direction of ABRM at present in nanoscale, 2-dimensional coating, and 3-dimensional scaffolds. Moreover, the referring main active substances and antioxidative properties were classified, and the positive roles of antioxidative materials for bone repair have also been clearly summarized in signaling pathways, antioxidant enzymes, cellular responses and animal levels.
活性氧（ROS）在生物体的许多生理或病理过程中具有重大影响。在骨缺损部位，过量产生的ROS会显著影响骨再生的动态平衡过程。许多有机和无机抗氧化剂表现出良好的成骨能力，已被广泛用于骨修复。总结抗氧化骨修复材料（ABRMs）对于为未来设计和制备具有抗氧化功能的成骨材料提供指导具有重要意义。在此，本综述介绍了目前ABRMs在纳米尺度、二维涂层和三维支架方面的主要研究方向。此外，对相关的主要活性物质和抗氧化性能进行了分类，并在信号通路、抗氧化酶、细胞反应和动物水平等方面明确总结了抗氧化材料对骨修复的积极作用。
