Clinic for Pediatric Medicine Helena, Ulica kneza Branimira 71, 10000 Zagreb, Croatia.
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, 31000 Osijek, Croatia.
Medicina (Kaunas). 2023 Dec 22;60(1):21. doi: 10.3390/medicina60010021.
The atopic march encompasses a sequence of allergic conditions, including atopic dermatitis, food allergy, allergic rhinitis, and asthma, that frequently develop in a sequential pattern within the same individual. It was introduced as a conceptual framework aimed at elucidating the developmental trajectory of allergic conditions during childhood. Following the introduction of this concept, it was initially believed that the atopic march represented the sole and definitive trajectory of the development of allergic diseases. However, this perspective evolved with the emergence of new longitudinal studies, which revealed that the evolution of allergic diseases is far more intricate. It involves numerous immunological pathological mechanisms and may not align entirely with the traditional concept of the atopic march. The objective of our review is to portray the atopic march alongside other patterns in the development of childhood allergic diseases, with a specific emphasis on the potential for a personalized approach to the prevention, diagnosis, and treatment of atopic conditions.
特应性进程涵盖一系列过敏状态，包括特应性皮炎、食物过敏、过敏性鼻炎和哮喘，这些在同一个体中常按序发生。它被引入作为一个概念框架，旨在阐明儿童时期过敏状态的发展轨迹。该概念引入后，最初认为特应性进程代表了过敏疾病发展的唯一和确定轨迹。然而，随着新的纵向研究的出现，这一观点发生了演变，这些研究表明过敏疾病的演变要复杂得多。它涉及许多免疫学病理机制，可能不完全符合特应性进程的传统概念。我们的综述旨在描绘特应性进程与儿童期过敏疾病发展的其他模式，特别强调特应性疾病预防、诊断和治疗的个体化方法的潜力。
