Mimi Korean Medicine Clinic, Seoul 05616, Republic of Korea.
College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
Medicina (Kaunas). 2023 Dec 30;60(1):76. doi: 10.3390/medicina60010076.
: Korean and traditional Chinese medicine state that pyrite is effective for fracture treatment, but supporting clinical data are limited. This systematic review aimed to investigate the therapeutic role of Chinese patent medicine containing pyrite (CPMP) in clinical treatment for fractures. : Seven electronic databases were searched using the keywords "pyrite", "pyritum", and "zirantong" between inception and December 2022, yielding 29 published clinical studies. Randomized controlled trials that included CPMP were considered eligible regardless of the fracture type. Quality assessment and meta-analysis of the included RCTs were also performed. : Most studies showed high heterogeneity (I > 50%) and significant results ( < 0.05). Compared to the results of the control group, CPMP was more effective in terms of the primary outcome related to the efficacy rate, including the total effective rate, callus growth rate, bone union, and edema disappearance time (all < 0.00001) and in terms of secondary outcomes related to pain reduction, namely pain intensity and pain disappearance time, than the control group (both < 0.01). CPMP was more effective than the control group in terms of erythrocyte sedimentation rate ( < 0.01), hematocrit ( < 0.01), erythrocyte aggregation ( < 0.05), and plasma viscosity ( < 0.05). CPMP did not cause serious side effects, and the incidence of complications was significantly less than that in the control group. : CPMP may be a safe and effective alternative treatment for fractures and may be beneficial in preventing postoperative complications, reducing pain, relieving symptoms, and accelerating healing.
: 韩医和中医认为黄铁矿对骨折治疗有效，但支持其临床疗效的数据有限。本系统评价旨在探讨含黄铁矿的中成药（CPMP）在骨折临床治疗中的治疗作用。: 检索了从建库至 2022 年 12 月 7 个电子数据库，使用“pyrite”“pyritum”和“zirantong”等关键词，共获得 29 项已发表的临床研究。纳入的 RCT 无论骨折类型如何，均认为只要包含 CPMP 即为合格研究。还对纳入的 RCT 进行了质量评估和荟萃分析。: 大多数研究显示高度异质性（I > 50%）和显著结果（ < 0.05）。与对照组相比，CPMP 在与疗效相关的主要结局方面更有效，包括总有效率、骨痂生长率、骨愈合和肿胀消退时间（均 < 0.00001），以及与疼痛缓解相关的次要结局，即疼痛强度和疼痛消退时间（均 < 0.01）。CPMP 在红细胞沉降率（ < 0.01）、红细胞压积（ < 0.01）、红细胞聚集（ < 0.05）和血浆黏度（ < 0.05）方面优于对照组。CPMP 未引起严重不良反应，并发症发生率明显低于对照组。: CPMP 可能是骨折的一种安全有效的替代治疗方法，可能有助于预防术后并发症、减轻疼痛、缓解症状和加速愈合。
