Moustakli Efthalia, Stavros Sofoklis, Katopodis Periklis, Skentou Charikleia, Potiris Anastasios, Panagopoulos Periklis, Domali Ekaterini, Arkoulis Ioannis, Karampitsakos Theodoros, Sarafi Eleftheria, Michaelidis Theologos M, Zachariou Athanasios, Zikopoulos Athanasios
Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Third Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Cells. 2025 Jan 2;14(1):36. doi: 10.3390/cells14010036.
Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted reproductive technologies such as in vitro fertilization (IVF). An essential component of innate immunity, the NLR family pyrin domain-containing 3 (NLRP3) inflammasome is one of the major mediators of inflammatory responses, and its activation is closely linked to oxidative stress. This interaction contributes to a decline in oocyte quality, reduced fertilization potential, and impaired embryo development. In the ovarian milieu, oxidative stress and NLRP3 inflammasome activation interact intricately, and their combined effects on oocyte competence and reproductive outcomes are significant. The aims of this review are to examine these molecular mechanisms and to explore therapeutic strategies targeting oxidative stress and NLRP3 inflammasome activity, with the goal of enhancing female fertility and improving clinical outcomes in reproductive health.
慢性炎症日益被认为是女性生殖健康的关键因素；它影响自然受孕以及体外受精（IVF）等辅助生殖技术的结果。NLR家族含pyrin结构域3（NLRP3）炎性小体作为固有免疫的重要组成部分，是炎症反应的主要介质之一，其激活与氧化应激密切相关。这种相互作用导致卵母细胞质量下降、受精潜力降低以及胚胎发育受损。在卵巢微环境中，氧化应激与NLRP3炎性小体激活复杂地相互作用，它们对卵母细胞能力和生殖结果的综合影响显著。本综述的目的是研究这些分子机制，并探索针对氧化应激和NLRP3炎性小体活性的治疗策略，以提高女性生育能力并改善生殖健康的临床结果。
