Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania.
Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania.
Nutrients. 2024 Jan 15;16(2):257. doi: 10.3390/nu16020257.
Obesity and aging are associated with an inflammatory state, which represents the common background for a wide range of diseases. This study aims to explore the correlation between hsCRP, IL-1β, IL-6, TNF-α, IFN-γ, and white blood cell count (WBC) and adipometrics (arm, waist, and hip circumferences: AC, WC, HC; total body fat mass: TBFM, visceral fat level: VFL, body mass index: BMI; waist/hip ratio: WHR; waist/height ratio: WHtR) in young and healthy adults aged 20-35 years old. The subjects were divided by BMI into the overweight/obesity (OW/OB) group and normal weight (NW) group, and by hsCRP level into Group 1 (<1 mg/L), Group 2 (≥1-2.99 mg/L), and Group 3 (≥3 mg/L). The concentration of all inflammatory biomarkers was significantly higher in the OW/OB group compared to the NW group, with the exception of IL-1β. Significant positive correlations were found between hsCRP, TNF-α, WBC, and all adipometrics; between IL-6 and WHR, WHtR, BMI, TBFM, and VFL; and between IFN-γ and HC, BMI, and TBFM. IL-1β correlates positively with WHR and VFL. In Groups 1-3, all the differences between the adipometrics showed significant differences. Subclinical inflammation persists in association with being overweight and obese in healthy young adults aged 20-35 years old.
肥胖和衰老与炎症状态有关，炎症状态是多种疾病的共同背景。本研究旨在探讨 hsCRP、IL-1β、IL-6、TNF-α、IFN-γ 和白细胞计数（WBC）与体脂参数（臂围、腰围和臀围：AC、WC、HC；全身脂肪量：TBFM、内脏脂肪水平：VFL、体重指数：BMI；腰臀比：WHR；腰高比：WHtR）在 20-35 岁年轻健康成年人中的相关性。受试者根据 BMI 分为超重/肥胖（OW/OB）组和正常体重（NW）组，根据 hsCRP 水平分为第 1 组（<1mg/L）、第 2 组（≥1-2.99mg/L）和第 3 组（≥3mg/L）。与 NW 组相比，OW/OB 组所有炎症生物标志物的浓度均显著升高，除了 IL-1β。hsCRP、TNF-α、WBC 与所有体脂参数呈显著正相关；IL-6 与 WHR、WHtR、BMI、TBFM 和 VFL 呈显著正相关；IFN-γ 与 HC、BMI 和 TBFM 呈显著正相关。IL-1β 与 WHR 和 VFL 呈正相关。在第 1-3 组中，所有体脂参数之间的差异均有显著差异。在 20-35 岁的健康年轻成年人中，超重和肥胖与亚临床炎症持续存在相关。
