Głosz Karolina, Fabin Magdalena, Janasik Patryk, Kołodziej Weronika, Stolarczyk Agnieszka, Jarosz Tomasz
Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.
Faculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
Sensors (Basel). 2024 Jan 10;24(2):0. doi: 10.3390/s24020424.
The aims of this study were to investigate the potential of utilising molecularly imprinted polycarbazole layers to detect highly toxic picric acid (PA) and to provide information about their performance. Quantum chemical calculations showed that strong interactions occur between PA and carbazole (bond energy of approximately 31 kJ/mol), consistent with the theoretical requirements for effective molecular imprinting. The performance of the sensors, however, was found to be highly limited, with the observed imprinting factor values for polycarbazole (PCz) layers being 1.77 and 0.95 for layers deposited on Pt and glassy carbon (GC) electrodes, respectively. Moreover, the molecularly imprinted polymer (MIP) layers showed worse performance than unmodified Pt or GC electrodes, for which the lowest limit of detection (LOD) values were determined (LOD values of 0.09 mM and 0.26 mM, respectively, for bare Pt and MIP PCz/Pt, as well as values of 0.11 mM and 0.57 mM for bare GC and MIP PCz/GC). The MIP layers also showed limited selectivity and susceptibility to interfering agents. An initial hypothesis on the reasons for such performance was postulated based on the common properties of conjugated polymers.
本研究的目的是探究利用分子印迹聚咔唑层检测高毒性苦味酸（PA）的潜力，并提供有关其性能的信息。量子化学计算表明，PA与咔唑之间存在强相互作用（键能约为31 kJ/mol），这与有效分子印迹的理论要求一致。然而，发现传感器的性能非常有限，沉积在铂和玻碳（GC）电极上的聚咔唑（PCz）层的观察到的印迹因子值分别为1.77和0.95。此外，分子印迹聚合物（MIP）层的性能比未修饰的铂或GC电极差，未修饰电极的最低检测限（LOD）值已确定（裸铂和MIP PCz/铂的LOD值分别为0.09 mM和0.26 mM，裸GC和MIP PCz/GC的LOD值分别为0.11 mM和0.57 mM）。MIP层对干扰剂的选择性和敏感性也有限。基于共轭聚合物的共同特性，对这种性能的原因提出了初步假设。
