West China Hospital of Sichuan University, Chengdu, China.
Chengdu Fuxing Hospital, Chengdu, China.
Integr Cancer Ther. 2024 Jan-Dec;23:15347354241226667. doi: 10.1177/15347354241226667.
Breast cancer is the most prevalent form of cancer in women. Despite significant advances in conventional treatment, additional safer complementary treatment options are needed. Recently, ozone therapy has been considered as a type of medical adjunctive treatment that could inhibit cancer cell survival and reduce chemoresistance. However, only a few studies have been conducted on its use in breast cancer, and the optimal dosage and time of administration are unknown. Currently, preclinical studies suggest that ozone alone or in combination with chemotherapy is an effective method for inhibiting breast cancer cell growth. However, rather than investigating the effects of ozone as an antitumor therapy, current clinical trials have generally assessed its effect as an adjunctive therapy for reducing chemotherapy-induced side effects, increasing oxygen tension, normalizing blood flow, restoring blood lymphocytes more rapidly, and reducing fatigue symptoms. In this article, the use of ozone as a medical adjunctive treatment for breast cancer and its role in integrative therapy are summarized and discussed.
乳腺癌是女性最常见的癌症。尽管在常规治疗方面取得了重大进展，但仍需要更安全的补充治疗选择。最近，臭氧治疗已被认为是一种可以抑制癌细胞存活和降低化疗耐药性的辅助治疗方法。然而，只有少数研究探讨了其在乳腺癌中的应用，其最佳剂量和给药时间尚不清楚。目前，临床前研究表明，臭氧单独或联合化疗是抑制乳腺癌细胞生长的有效方法。然而，目前的临床试验并没有研究臭氧作为抗肿瘤治疗的效果，而是通常评估其作为辅助治疗的效果，以减轻化疗引起的副作用、增加氧张力、使血流正常化、更快地恢复血淋巴细胞、减轻疲劳症状。本文总结和讨论了臭氧作为乳腺癌辅助治疗的应用及其在综合治疗中的作用。
