Multicenter Post Graduation Program in Physiological Sciences, Brazilian Society of Physiology, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
Laboratory of Biochemistry and Molecular Biology of the Exercise, University of Sao Paulo (USP), São Paulo-SP, Brazil.
Curr Hypertens Rev. 2024;20(1):52-56. doi: 10.2174/0115734021277791240102041632.
Arterial hypertension is a multifactorial clinical condition characterized by higher blood pressure levels. The main treatment for controlling high blood pressure consists of drug therapy, but the scientific literature has been pointing to the efficiency of aerobic and resistance exercises acting in a therapeutic and/or preventive way to reduce and control the blood pressure levels. Resistance training is characterized by sets and repetitions on a given muscle segment that uses overload, such as machine weights, bars, and dumbbells. As it successfully affects a number of variables associated to practitioners' functional and physiological features as well as emotional and social variables, resistance training has been a crucial part of physical exercise programs. Several reports highlight the various adaptive responses it provides, with a focus on the improvement in strength, balance, and muscular endurance that enables a more active and healthy lifestyle. Resistance training programs that are acute, sub-chronic, or chronic can help people with varying ages, conditions, and pathologies reduce their arterial hypertension. However, molecular mechanisms associated with resistance training to reduce blood pressure still need to be better understood. Thus, we aimed to understand the main effects of resistance training on blood pressure as well as the associated molecular mechanisms.
高血压是一种多因素的临床病症，其特征是血压水平升高。控制高血压的主要治疗方法包括药物治疗，但科学文献一直指出，有氧运动和抗阻运动在治疗和/或预防方面具有降低和控制血压水平的功效。抗阻训练的特点是对给定肌肉部位进行多组和多次重复，使用超负荷，如机器重量、杠铃和哑铃。由于它成功地影响了与练习者的功能和生理特征以及情感和社会变量相关的许多变量，抗阻训练一直是体育锻炼计划的重要组成部分。许多报告强调了它提供的各种适应反应，重点是提高力量、平衡和肌肉耐力，从而实现更积极和健康的生活方式。急性、亚慢性或慢性的抗阻训练计划可以帮助不同年龄、身体状况和病理的人群降低他们的动脉高血压。然而，与抗阻训练降低血压相关的分子机制仍需要更好地理解。因此，我们旨在了解抗阻训练对血压的主要影响以及相关的分子机制。
