Qin Shuguang, Tian Zhenjun, Boidin Maxime, Buckley Benjamin J R, Thijssen Dick H J, Lip Gregory Y H
Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University, Xi'an, China.
Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Physiol. 2022 Jun 29;13:935772. doi: 10.3389/fphys.2022.935772. eCollection 2022.
Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular disease (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, including irisin, is associated with beneficial effects of exercise in CVD patients. The present review provides an overview of the role of exercise in cardiac rehabilitation of patients with myocardial infarction (MI). Further, the role of irisin as a motion-responsive molecule in improving vascular and metabolic health is explored. Possible mechanism of cardioprotective effect of irisin-mediated exercise on myocardial infarction are also summarized in this review. Irisin is associated with reduced inflammation, antioxidant properties, and anti-apoptotic effect, implying that it is a potential key mediator of the beneficial effects of exercise on vascular and metabolic health. The findings show that irisin is a promising therapeutic target for treatment of patients with cardiovascular disease, particularly post-MI. Further research should be conducted to elucidate the potential mechanisms of cardioprotective effects of irisin and explored whether irisin induced by exercise exerts rehabilitation effects post-MI.
规律运动是治疗和预防心血管疾病（CVD）的一种有效的非药物疗法。运动的治疗益处部分是通过改善血管和提高代谢健康来介导的。包括鸢尾素在内的运动反应性肌细胞因子的释放与运动对CVD患者的有益作用相关。本综述概述了运动在心肌梗死（MI）患者心脏康复中的作用。此外，还探讨了鸢尾素作为一种运动反应性分子在改善血管和代谢健康方面的作用。本综述还总结了鸢尾素介导的运动对心肌梗死的心脏保护作用的可能机制。鸢尾素与炎症减轻、抗氧化特性和抗凋亡作用相关，这意味着它是运动对血管和代谢健康有益作用的潜在关键介质。研究结果表明，鸢尾素是治疗心血管疾病患者，尤其是心肌梗死后患者的一个有前景的治疗靶点。应进一步开展研究，以阐明鸢尾素心脏保护作用的潜在机制，并探索运动诱导的鸢尾素是否对心肌梗死后发挥康复作用。
