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Current status and prospect of transcutaneous auricular vagus nerve stimulation for disorders of consciousness.

作者信息

Wang Yifei, Zhang Jinling, Zhai Weihang, Wang Yu, Li Shaoyuan, Yang Yi, Zheng Yanfeng, He Jianghong, Rong Peijing

机构信息

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

出版信息

Front Neurosci. 2024 Jan 8;17:1274432. doi: 10.3389/fnins.2023.1274432. eCollection 2023.


DOI:10.3389/fnins.2023.1274432
PMID:38260020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10800843/
Abstract

Disordered Consciousness (DOC) is among neurological disorders for which there is currently no admitted treatment. The pathogenesis of DOC is still unclear, covering a variety of indistinguishable types of diseases, high misdiagnosis rate and poor prognosis. Most treatments remain to be clarified in the future to provide adequate evidence for clinical guidance. Neuromodulation technology aims to regulate neural circuits to promote awakening more directly. At present, it is confirmed that the potential of transcutaneous auricular vagus nerve stimulation (taVNS) as a therapeutic tool is worth exploring in the context of consciousness disorders, as previously proposed for invasive forms of VNS, in which the means of stimulating the vagus nerve to change the brain areas related to cosciousness have also received widespread attention. In this paper, we review the literature on taVNS and DOC to better understand the current status and development prospect of taVNS treament as a non-invasive neuromodulation method with sensitivity and/or specificity at the single subject.

摘要

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引用本文的文献

[1]
Meta-Analysis of the Clinical Efficacy of Auricular Acupressure on Patients with Depression.

Alpha Psychiatry. 2025-2-28

[2]
Transcutaneous auricular vagus nerve stimulation as a potential therapy for attention deficit hyperactivity disorder: modulation of the noradrenergic pathway in the prefrontal lobe.

Front Neurosci. 2024-12-4

[3]
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本文引用的文献

[1]
Effects of simultaneous transcutaneous auricular vagus nerve stimulation and high-definition transcranial direct current stimulation on disorders of consciousness: a study protocol.

Front Neurol. 2023-8-24

[2]
A protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness.

Front Neurol. 2023-7-21

[3]
The impact of the human thalamus on brain-wide information processing.

Nat Rev Neurosci. 2023-7

[4]
Transcranial Magnetic Stimulation in Disorders of Consciousness: An Update and Perspectives.

Aging Dis. 2023-8-1

[5]
Study protocol: Developing telephone follow-up scale for patients with disorders of consciousness.

Front Public Health. 2023

[6]
Optimizing the modulation paradigm of transcutaneous auricular vagus nerve stimulation in patients with disorders of consciousness: A prospective exploratory pilot study protocol.

Front Neurosci. 2023-3-15

[7]
Transcutaneous vagus nerve stimulation and the realm of its therapeutic hopes and physiologic enigmas.

Auton Neurosci. 2022-12

[8]
Transcutaneous vagus nerve stimulation - A brief introduction and overview.

Auton Neurosci. 2022-12

[9]
Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis.

Brain Stimul. 2022

[10]
Hyperbaric oxygen therapy promotes consciousness, cognitive function, and prognosis recovery in patients following traumatic brain injury through various pathways.

Front Neurol. 2022-8-10

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