Kravetz D, Arderiu M, Bosch J, Fuster J, Visa J, Casamitjana R, Rodés J
Am J Physiol. 1987 Feb;252(2 Pt 1):G257-61. doi: 10.1152/ajpgi.1987.252.2.G257.
The study was aimed at investigating whether increased portal venous inflow (PVI) after portocaval shunt (PCS) in the rat is the result of selective splanchnic vasodilatation or whether it is part of a generalized circulatory disturbance. Rats with PCS (n = 9) and sham-operated controls (n = 8) were studied 2 wk after surgery by measuring cardiac output (CO), PVI, and hepatic artery flow (HAF) with radioactive microspheres. Plasma glucagon (GL) was measured by radioimmunoassay. PCS rats had increased CO (46.2 +/- 2.8 vs. 28.2 +/- 1.7 ml X min-1 X 100 g-1, P less than 0.001) and reduced arterial pressure and total peripheral resistance. PVI was markedly increased (7.7 +/- 0.7 vs. 4.3 +/- 0.2 ml X min-1 X 100 g-1, P less than 0.001), but this appeared to be part of a generalized circulatory disturbance, since when PVI is expressed as percent of CO no difference is observed between PCS and sham-operated rats (17.0 +/- 1.5 vs. 15.8 +/- 1.3%, NS), indicating the absence of a preferential splanchnic vasodilatation. GL increased after PCS (548 +/- 130 vs. 156 +/- 23 pg/ml, P less than 0.005), and significant correlations were observed between GL and CO (r = 0.787, P less than 0.001) and between GL and PVI (r = 0.806, P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
该研究旨在探究大鼠门腔分流术（PCS）后门静脉血流量增加（PVI）是选择性内脏血管扩张的结果，还是全身性循环障碍的一部分。通过放射性微球测量心输出量（CO）、PVI和肝动脉血流量（HAF），对术后2周的PCS大鼠（n = 9）和假手术对照组（n = 8）进行研究。采用放射免疫分析法测定血浆胰高血糖素（GL）。PCS大鼠的心输出量增加（46.2±2.8对28.2±1.7 ml·min⁻¹·100 g⁻¹，P＜0.001），动脉压和总外周阻力降低。PVI显著增加（7.7±0.7对4.3±0.2 ml·min⁻¹·100 g⁻¹，P＜0.001），但这似乎是全身性循环障碍的一部分，因为当PVI以心输出量的百分比表示时，PCS大鼠和假手术大鼠之间未观察到差异（17.0±1.5对15.8±1.3%，无显著性差异），表明不存在选择性内脏血管扩张。PCS后GL升高（548±130对156±23 pg/ml，P＜0.005），并且观察到GL与CO之间（r = 0.787，P＜0.001）以及GL与PVI之间（r = 0.806，P＜0.001）存在显著相关性。（摘要截断于250字）
